CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs. (Q36328196)

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12 February 2020

title

CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs (English)

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12

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Simon P Robinson

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Louis Chesler

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Florence Raynaud

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author name string

Mike I Walton

1

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Paul D Eve

2

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Angela Hayes

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Melanie R Valenti

4

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Alexis K De Haven Brandon

5

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Gary Box

6

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Albert Hallsworth

7

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Elizabeth L Smith

8

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Kathy J Boxall

9

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Michael Lainchbury

10

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Thomas P Matthews

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G Wynne Aherne

14

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John C Reader

15

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Suzanne A Eccles

18

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Ian Collins

19

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Michelle D Garrett

20

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language of work or name

English

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publication date

28 August 2012

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published in

Clinical Cancer Research

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volume

18

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issue

20

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page(s)

5650-5661

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describes a project that uses

12 February 2020

ImageQuant

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

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CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo

30 September 2017

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Constitutive activation of the DNA damage signaling pathway in acute myeloid leukemia with complex karyotype: potential importance for checkpoint targeting therapy.

29 June 2018

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Radiosensitization by Chir-124, a selective CHK1 inhibitor: effects of p53 and cell cycle checkpoints.

22 September 2018

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Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors

22 September 2018

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c-Myc initiates illegitimate replication of the ribonucleotide reductase R2 gene

22 September 2018

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10.1158/1078-0432.CCR-12-1322

22 September 2018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22929806%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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12 February 2020

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