Fasting activates macroautophagy in neurons of Alzheimer's disease mouse model but is insufficient to degrade amyloid-beta (Q36288628)

13 August 2017

Fasting activates macroautophagy in neurons of Alzheimer's disease mouse model but is insufficient to degrade amyloid-beta (English)

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13 August 2017

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Xigui Chen

1

1 reference

13 August 2017

Kanoh Kondo

2

1 reference

13 August 2017

Kazumi Motoki

3

1 reference

13 August 2017

Hidenori Homma

4

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13 August 2017

Hitoshi Okazawa

5

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13 August 2017

language of work or name

English

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publication date

14 July 2015

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13 August 2017

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13 August 2017

5

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13 August 2017

12115

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Creative Commons Attribution 4.0 International

13 August 2017

start time

14 July 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1038/srep12115

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cites work

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Autophagy and human diseases

30 September 2017

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Advances in the genetics of Parkinson disease

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Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.

30 September 2017

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

30 September 2017

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Short-term fasting induces profound neuronal autophagy

30 September 2017

1 reference

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Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle

30 September 2017

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Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome

30 September 2017

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LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization

30 September 2017

1 reference

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

30 September 2017

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

30 September 2017

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Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

30 September 2017

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Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum

30 September 2017

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

30 September 2017

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

30 September 2017

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In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

30 September 2017

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Enzyme replacement and enhancement therapies: lessons from lysosomal disorders

30 September 2017

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Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36

30 September 2017

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

30 September 2017

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

30 September 2017

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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

30 September 2017

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SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis

29 June 2018

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Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

22 September 2018

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JNK activation is associated with intracellular beta-amyloid accumulation.

22 September 2018

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22 September 2018

Identifiers

DOI

10.1038/SREP12115

1 reference

13 August 2017

1 reference

13 August 2017

1 reference