The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model. (Q36288534)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

title

The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Young Pyo Jang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Steffen Jockusch

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

author name string

Nathan E Fishkin

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Nicholas J Turro

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Janet R Sparrow

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

language of work or name

English

0 references

publication date

28 November 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

28 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

volume

104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

issue

49

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

page(s)

19273-19278

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

Characterization of dihydro-A2PE: an intermediate in the A2E biosynthetic pathway

28 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

Reductions in Serum Vitamin A Arrest Accumulation of Toxic Retinal Fluorophores: A Potential Therapy for Treatment of Lipofuscin-Based Retinal Diseases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

Controlling the pKa of the bacteriorhodopsin Schiff base by use of artificial retinal analogues

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

Visual pigments. V. Ground and excited-state acid dissociation constants of protonated all-trans retinal schiff base and correlation with theory

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin

29 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0708714104

Absolute configurational determination of an all-trans-retinal dimer isolated from photoreceptor outer segments

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0708714104

Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0708714104

Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0708714104

Electroretinographic evidence for altered phototransduction gain and slowed recovery from photobleaches in albino mice with a MET450 variant in RPE65

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0708714104

Mole quantity of RPE65 and its productivity in the generation of 11-cis-retinal from retinyl esters in the living mouse eye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0708714104

DNA Is a Target of the Photodynamic Effects Elicited in A2E-Laden RPE by Blue-Light Illumination

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0708714104

Mechanisms for the induction of HNE- MDA- and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0708714104

Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148280

Ocular Age Pigment “A2-E”: An Unprecedented Pyridinium Bisretinoid

22 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0708714104

21 January 2018

1 reference

12 December 2020

The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membrane

1 reference

12 December 2020

Effect of solution environment on the absorption maxima of Schiff bases of retinal

1 reference

12 December 2020

A water-soluble polylysine-retinaldehyde Schiff base. Stability in aqueous and nonaqueous environments

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0708714104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048333%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference