Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate (Q33821589)

29 July 2017

Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate (English)

1 reference

29 July 2017

4

Koji Nakanishi

1 reference

29 July 2017

Nathan E Fishkin

1

1 reference

29 July 2017

Janet R Sparrow

series ordinal

2

1 reference

29 July 2017

Rando Allikmets

series ordinal

3

1 reference

29 July 2017

language of work or name

English

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publication date

3 May 2005

1 reference

Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

1 reference

29 July 2017

102

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29 July 2017

20

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29 July 2017

7091-7096

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RPE lipofuscin and its role in retinal pathobiology

29 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Do blue light filters confer protection against age-related macular degeneration?

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Dark adaptation and the retinoid cycle of vision

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

A2E, a byproduct of the visual cycle

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Delayed dark-adaptation and lipofuscin accumulation in abcr+/- mice: implications for involvement of ABCR in age-related macular degeneration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

4 July 2018

When lysosomes get old.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Distribution of pigment epithelium autofluorescence in retinal disease state recorded in vivo and its change over time

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

In vivo fundus autofluorescence in macular dystrophies

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Basic mechanisms underlying the production of photochemical lesions in the mammalian retina

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Influence of early photoreceptor degeneration on lipofuscin in the retinal pigment epithelium

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Reduced phagosomal content of the retinal pigment epithelium in response to retinoid deprivation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Histologic analysis of photochemical lesions produced in rhesus retina by short-wave-length light

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin

4 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501266102

Interaction of A2E with model membranes. Implications to the pathogenesis of age-related macular degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501266102

A2-rhodopsin: a new fluorophore isolated from photoreceptor outer segments

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501266102

Absolute configurational determination of an all-trans-retinal dimer isolated from photoreceptor outer segments

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501266102

Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Effect of Rpe65 knockout on accumulation of lipofuscin fluorophores in the retinal pigment epithelium.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1129110

Retinal age pigments generated by self-assembling lysosomotropic detergents

29 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501266102

Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin

21 January 2018

1 reference

12 December 2020

The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium

1 reference

12 December 2020

Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells

1 reference

12 December 2020

Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium

1 reference

12 December 2020

In vivo measurement of lipofuscin in Stargardt's disease--Fundus flavimaculatus

1 reference

12 December 2020

Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin

1 reference

12 December 2020

The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membrane

1 reference

12 December 2020

Age-related Macular Degeneration

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0501266102

1 reference

29 July 2017

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1 reference

29 July 2017

1 reference