Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants (Q36277286)

13 August 2017

Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants (English)

1 reference

protein heterodimerization activity

13 August 2017

1 reference

1 reference

Xue Wu

1

1 reference

13 August 2017

Jiani Yin

2

1 reference

13 August 2017

Jeremy Simpson

3

1 reference

13 August 2017

Kyoung-Han Kim

4

1 reference

13 August 2017

Shengqing Gu

5

1 reference

13 August 2017

Jenny H Hong

6

1 reference

13 August 2017

Peter Bayliss

7

1 reference

13 August 2017

Peter H Backx

8

1 reference

13 August 2017

Benjamin G Neel

9

1 reference

13 August 2017

Toshiyuki Araki

10

1 reference

13 August 2017

language of work or name

English

0 references

publication date

23 July 2012

1 reference

Molecular and Cellular Biology

13 August 2017

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13 August 2017

32

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13 August 2017

3872-3890

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13 August 2017

19

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describes a project that uses

13 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3457534/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Raf family kinases: old dogs have learned new tricks

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Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes

30 September 2017

1 reference

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Noonan syndrome and clinically related disorders

30 September 2017

1 reference

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MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation

30 September 2017

1 reference

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Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation

30 September 2017

1 reference

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Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling

30 September 2017

1 reference

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

30 September 2017

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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

30 September 2017

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

30 September 2017

1 reference

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Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt

30 September 2017

1 reference

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Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation

30 September 2017

1 reference

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Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload

30 September 2017

1 reference

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A restricted spectrum of NRAS mutations causes Noonan syndrome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling

30 September 2017

1 reference

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C-Raf inhibits MAPK activation and transformation by B-Raf(V600E).

30 September 2017

1 reference

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A dimerization-dependent mechanism drives RAF catalytic activation

30 September 2017

1 reference

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Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair

30 September 2017

1 reference

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The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

30 September 2017

1 reference

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Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

30 September 2017

1 reference

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The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

30 September 2017

1 reference

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Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy

30 September 2017

1 reference

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Germline gain-of-function mutations in RAF1 cause Noonan syndrome

30 September 2017

1 reference

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Raf kinases: function, regulation and role in human cancer

30 September 2017

1 reference

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Germline gain-of-function mutations in SOS1 cause Noonan syndrome

30 September 2017

1 reference

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Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations

30 September 2017

1 reference

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Stops along the RAS pathway in human genetic disease

30 September 2017

1 reference

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Regulation and role of Raf-1/B-Raf heterodimerization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Germline KRAS mutations cause Noonan syndrome

30 September 2017

1 reference

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Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling

30 September 2017

1 reference

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Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

30 September 2017

1 reference

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Noonan syndrome and related disorders: genetics and pathogenesis

30 September 2017

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BRAF mutation detection and identification by cycling temperature capillary electrophoresis

30 September 2017

1 reference

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Oncogenic Ras in tumour progression and metastasis

30 September 2017

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Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

30 September 2017

1 reference

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The RAF proteins take centre stage

30 September 2017

1 reference

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Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

30 September 2017

1 reference

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

30 September 2017

1 reference

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Mechanisms of regulating the Raf kinase family

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Prevention of hypertrophy by overexpression of Kv4.2 in cultured neonatal cardiomyocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Dephosphorylation of Ser-259 regulates Raf-1 membrane association

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Positive and negative regulation of Raf kinase activity and function by phosphorylation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Active Ras induces heterodimerization of cRaf and BRaf

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

The Ullrich-Noonan syndrome (Turner phenotype).

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Mutational patterns and novel mutations of the BRAF gene in a large cohort of Korean patients with papillary thyroid carcinoma.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

RAS oncogenes: the first 30 years.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

The Eleventh Datta Lecture. The structural basis for substrate recognition and control by protein kinases.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457534

22 September 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22826437

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.00751-12

1 reference

13 August 2017

1 reference

13 August 2017

1 reference