Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function (Q36265691)

13 August 2017

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function (English)

1 reference

13 August 2017

7

Matthias Gaestel

0 references

Natthakan Thongon

Natthakan Thongon

6

0 references

Christopher Tiedje

Christopher Tiedje

4

0 references

Chiara Zucal

Chiara Zucal

5

0 references

Vito G D'Agostino

Vito Giuseppe D'Agostino

1

0 references

Barbara Mantelli

Barbara Mantelli

3

0 references

Alessandro Provenzani

Alessandro Provenzani

12

0 references

Pierfausto Seneci

Pierfausto Seneci

10

0 references

author name string

Preet Lal

2

1 reference

13 August 2017

Elisa Latorre

8

1 reference

13 August 2017

Luciana Marinelli

9

1 reference

13 August 2017

Marialaura Amadio

11

1 reference

13 August 2017

language of work or name

English

0 references

publication date

10 November 2015

1 reference

13 August 2017

1 reference

13 August 2017

5

1 reference

13 August 2017

16478

1 reference

Creative Commons Attribution 4.0 International

13 August 2017

start time

10 November 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4639722/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/srep16478

0 references

cites work

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Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity

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Hu antigen R (HuR) is a positive regulator of the RNA-binding proteins TDP-43 and FUS/TLS: implications for amyotrophic lateral sclerosis.

30 September 2017

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Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation

30 September 2017

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Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis

30 September 2017

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Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is required for initiation of experimental autoimmune encephalomyelitis

30 September 2017

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A novel high throughput biochemical assay to evaluate the HuR protein-RNA complex formation

30 September 2017

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Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells

30 September 2017

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Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL-6/STAT3/NF-kB signaling pathways

30 September 2017

1 reference

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The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding

30 September 2017

1 reference

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Mechanisms coordinating ELAV/Hu mRNA regulons

30 September 2017

1 reference

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Tanshinone derivatives: a patent review (January 2006 - September 2012).

30 September 2017

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Recognition of the let-7g miRNA precursor by human Lin28B

30 September 2017

1 reference

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The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation

30 September 2017

1 reference

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TanshinoneIIA ameliorates inflammatory microenvironment of colon cancer cells via repression of microRNA-155.

30 September 2017

1 reference

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Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells.

30 September 2017

1 reference

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HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Posttranscriptional regulation of cancer traits by HuR

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

30 September 2017

1 reference

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HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Mechanisms of TNFα regulation in uveitis: focus on RNA-binding proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Loss of repression of HuR translation by miR-16 may be responsible for the elevation of HuR in human breast carcinoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Myocardial knockdown of mRNA-stabilizing protein HuR attenuates post-MI inflammatory response and left ventricular dysfunction in IL-10-null mice.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Tumor necrosis factor blockade and the risk of viral infection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Functional analysis of CDKN2A/p16INK4a 5'-UTR variants predisposing to melanoma

30 September 2017

1 reference

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Post-transcriptional regulons coordinate the initiation and resolution of inflammation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-alpha mRNA.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes

30 September 2017

1 reference

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Coordinated posttranscriptional mRNA population dynamics during T-cell activation

30 September 2017

1 reference

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Anticancer effects of tanshinone I in human non-small cell lung cancer.

30 September 2017

1 reference

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Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR

30 September 2017

1 reference

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Phosphorylation of HuR by Chk2 regulates SIRT1 expression

30 September 2017

1 reference

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New developments in the chemistry and biology of the bioactive constituents of Tanshen

30 September 2017

1 reference

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Global alterations in mRNA polysomal recruitment in a cell model of colorectal cancer progression to metastasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

A new anti-inflammatory agent KL-1037 represses proinflammatory cytokine and inducible nitric oxide synthase (iNOS) gene expression in activated microglia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

The anti-inflammatory carbazole, LCY-2-CHO, inhibits lipopolysaccharide-induced inflammatory mediator expression through inhibition of the p38 mitogen-activated protein kinase signaling pathway in macrophages.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3'-untranslated region of tumor necrosis factor-alpha messenger RNA.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

The kinetics of competitive radioligand binding predicted by the law of mass action.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Anti-angiogenic effect of tanshinone IIA involves inhibition of the VEGF/VEGFR2 pathway in vascular endothelial cells.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Human antigen R mediated post-transcriptional regulation of epithelial-mesenchymal transition related genes in diabetic nephropathy.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glioblastoma cells.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Cryptotanshinone attenuates cardiac fibrosis via downregulation of COX-2, NOX-2, and NOX-4.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Targeting transmembrane TNF-α suppresses breast cancer growth

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

The PKCbeta/HuR/VEGF pathway in diabetic retinopathy.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Immunoprecipitation of mRNA-protein complexes.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-alpha, IL-1beta and IL-6 in activated RAW 264.7 cells

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

The role of 3'-untranslated region (3'-UTR) mediated mRNA stability in cardiovascular pathophysiology.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639722

Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26553968

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26553968

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP16478

1 reference

13 August 2017

1 reference

13 August 2017

1 reference