The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glioblastoma cells. (Q48285231)

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11 March 2020

title

The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glioblastoma cells (English)

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11 March 2020

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9

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11 March 2020

Benjamin Heng

4

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11 March 2020

Alaina J Ammit

6

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11 March 2020

Thomas Grewal

10

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11 March 2020

author name string

F M S Gurgis

1

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11 March 2020

Y T Yeung

2

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11 March 2020

M X M Tang

3

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11 March 2020

M Buckland

5

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11 March 2020

J Haapasalo

7

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11 March 2020

H Haapasalo

8

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11 March 2020

L Munoz

11

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11 March 2020

language of work or name

English

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publication date

4 August 2014

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11 March 2020

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11 March 2020

volume

34

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11 March 2020

issue

22

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11 March 2020

page(s)

2934-2942

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https://scigraph.springernature.com/pub.10.1038/onc.2014.225

11 March 2020

exact match

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cites work

Interleukins in glioblastoma pathophysiology: implications for therapy.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

IL-1β potently stabilizes IL-6 mRNA in human astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

p38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Regulation of cyclooxygenase-2 and cytosolic phospholipase A2 gene expression by lipopolysaccharide through the RNA-binding protein HuR: involvement of NADPH oxidase, reactive oxygen species and mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Role of HuR and p38MAPK in ultraviolet B-induced post-transcriptional regulation of COX-2 expression in the human keratinocyte cell line HaCaT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Nitric oxide-p38 MAPK signaling stabilizes mRNA through AU-rich element-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

MAPKAP kinases - MKs - two's company, three's a crowd

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

High expression of HuR in cytoplasm, but not nuclei, is associated with malignant aggressiveness and prognosis in bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

mRNA stability alterations mediated by HuR are necessary to sustain the fast growth of glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

The RNA-binding protein HuR promotes glioma growth and treatment resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Feedback regulation of EGFR signalling: decision making by early and delayed loops.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-beta (TR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

IL-1beta induces expression of matrix metalloproteinase-9 and cell migration via a c-Src-dependent, growth factor receptor transactivation in A549 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Fluorescence polarization binding assay to develop inhibitors of inactive p38alpha mitogen-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Mitogen-activated protein kinase-activated protein kinase 2 in neuroinflammation, heat shock protein 27 phosphorylation, and cell cycle: role and targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Nuclear HuR accumulation through phosphorylation by Cdk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Nuclear export of proteins and drug resistance in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

The RNA-binding protein HuR stabilizes cytosolic phospholipase A2α mRNA under interleukin-1β treatment in non-small cell lung cancer A549 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

The definition of primary and secondary glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.225

HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3' untranslated regions of cytokine and angiogenic factor mRNAs

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25088200