MET meet adaptors: functional and structural implications in downstream signalling mediated by the Met receptor (Q36245150)

13 August 2017

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title

MET meet adaptors: functional and structural implications in downstream signalling mediated by the Met receptor (English)

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13 August 2017

Victor M Bolanos-Garcia

object named as

Victor Martin Bolanos-Garcia

series ordinal

1

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publication date

1 August 2005

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Molecular and Cellular Biochemistry

13 August 2017

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13 August 2017

276

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13 August 2017

1-2

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13 August 2017

149-157

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https://scigraph.springernature.com/pub.10.1007/s11010-005-3696-6

13 August 2017

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Characterization of the rearranged tpr-met oncogene breakpoint

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Mutational analysis of acute-phase response factor/Stat3 activation and dimerization

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Protein-tyrosine kinases

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Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

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Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

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Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src)

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pp60c-src enhances the acetylcholine receptor-dependent catecholamine release in vaccinia virus-infected bovine adrenal chromaffin cells.

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Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein

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Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

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Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex

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Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

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Identification of a novel type of alternative splicing of a tyrosine kinase receptor. Juxtamembrane deletion of the c-met protein kinase C serine phosphorylation regulatory site.

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Novel interaction partners of the TPR/MET tyrosine kinase

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Specificity of the PTB domain of Shc for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine

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Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells

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SH3 domains: complexity in moderation

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Scatter factor receptors are key players in a unique multistep program leading to invasive growth.

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Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro

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Scatter factor/hepatocyte growth factor is essential for liver development

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The role of STATs in transcriptional control and their impact on cellular function

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12 December 2020

The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase

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12 December 2020

Activated ERK2 interacts with and phosphorylates the docking protein GAB1.

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12 December 2020

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells

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Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1.

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

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NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos

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12 December 2020

Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

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Alternatively spliced juxtamembrane domain of a tyrosine kinase receptor is a multifunctional regulatory site. Deletion alters cellular tyrosine phosphorylation pattern and facilitates binding of phosphatidylinositol-3-OH kinase to the hepatocyte gr

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12 December 2020

Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain

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Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons.

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Scatter factor induces blood vessel formation in vivo

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Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and inducti

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Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

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12 December 2020

The interplay between Src family kinases and receptor tyrosine kinases

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12 December 2020

Structure, function, and biology of SHIP proteins

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12 December 2020

Three-dimensional structure of the Stat3beta homodimer bound to DNA

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12 December 2020

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a

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12 December 2020

Structural and evolutionary division of phosphotyrosine binding (PTB) domains.

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12 December 2020

Identification of epidermal growth factor receptor- Grb2-associated binder-1-SHP-2 complex formation and its functional loss during neoplastic cell progression.

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12 December 2020

Role of the Src homology 2 (SH2) domain and C-terminus tyrosine phosphorylation sites of SH2-containing inositol phosphatase (SHIP) in the regulation of insulin-induced mitogenesis

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12 December 2020

Hepatocyte growth factor-induced differential activation of phospholipase cgamma 1 and phosphatidylinositol 3-kinase is regulated by tyrosine phosphatase SHP-1 in astrocytes

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12 December 2020

ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gab1): role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation

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12 December 2020

Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos.

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12 December 2020

SH2 domains recognize specific phosphopeptide sequences

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12 December 2020

Differential requirement of Grb2 and PI3-kinase in HGF/SF-induced cell motility and tubulogenesis

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12 December 2020

Signaling pathways in the induction of c-met receptor expression by its ligand scatter factor/hepatocyte growth factor in human glioblastoma.

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12 December 2020

Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules

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12 December 2020

Regulation of Ras and Rho small G proteins by SHP-2.

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12 December 2020

Signaling via Shc family adapter proteins

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12 December 2020

SH2 and PTB domains in tyrosine kinase signaling

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12 December 2020

Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways

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12 December 2020

Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

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12 December 2020

The "Gab" in signal transduction.

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12 December 2020

Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions

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12 December 2020

The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants

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12 December 2020

SH2 and SH3 domains: from structure to function

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12 December 2020

Essential role of Gab1 for signaling by the c-Met receptor in vivo

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12 December 2020

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12 December 2020

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

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12 December 2020

Myristylation and palmitylation of Src family members: the fats of the matter

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12 December 2020

SHP-1 associates with both platelet-derived growth factor receptor and the p85 subunit of phosphatidylinositol 3-kinase

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12 December 2020

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

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12 December 2020

A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor

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12 December 2020

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity

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12 December 2020

Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma.

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12 December 2020

Crosstalk between steroid receptors and the c-Src-receptor tyrosine kinase pathways: implications for cell proliferation

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12 December 2020

Evolution of Shc functions from nematode to human

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12 December 2020

Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.

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12 December 2020

The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein

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12 December 2020

Expression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression

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12 December 2020

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase

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12 December 2020

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

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12 December 2020

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

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12 December 2020

10.1007/S11010-005-3696-6

Identifiers

DOI

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13 August 2017

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