Leukotriene B4 receptor and the function of its helix 8. (Q36208372)

12 August 2017

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title

Leukotriene B4 receptor and the function of its helix 8. (English)

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12 August 2017

Takehiko Yokomizo

2

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author name string

Toshiaki Okuno

1

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12 August 2017

Tetsuya Hori

3

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12 August 2017

Masashi Miyano

4

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12 August 2017

Takao Shimizu

5

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12 August 2017

language of work or name

English

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publication date

26 July 2005

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Journal of Biological Chemistry

12 August 2017

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12 August 2017

280

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12 August 2017

37

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12 August 2017

32049-32052

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Arachidonic acid cascade and signal transduction

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International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors

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Heterogeneity of human polymorphonuclear leukocyte receptors for leukotriene B4. Identification of a subset of high affinity receptors that transduce the chemotactic response

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Leukotriene B4 binding to human neutrophils

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Solubilization and characterization of leukotriene B4 receptor-GTP binding protein complex from porcine spleen

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Characterization of the leukotriene B4 receptor in porcine leukocytes. Separation and reconstitution with heterotrimeric GTP-binding proteins.

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A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

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Chemoattractant receptors activate distinct pathways for chemotaxis and secretion. Role of G-protein usage

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Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release

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Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis

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BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis

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Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues.

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Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4.

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Requirement for leukotriene B4 receptor 1 in allergen-induced airway hyperresponsiveness

21 January 2018

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Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene

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Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms

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A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders

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Molecular cloning and characterization of another leukotriene B4 receptor

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A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization

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Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor

21 January 2018

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Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2

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Crystal structure of rhodopsin: A G protein-coupled receptor

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Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function

21 January 2018

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Structure-based analysis of GPCR function: conformational adaptation of both agonist and receptor upon leukotriene B4 binding to recombinant BLT1.

21 January 2018

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Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein

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Seven-transmembrane receptors: crystals clarify

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Helix 8 of the leukotriene B4 receptor is required for the conformational change to the low affinity state after G-protein activation

21 January 2018

1 reference

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Structural determinants regulating expression of the high affinity leukotriene B4 receptor: involvement of dileucine motifs and alpha-helix VIII.

21 January 2018

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Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization

21 January 2018

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A combinatorial G protein-coupled receptor reconstitution system on budded baculovirus. Evidence for Galpha and Galphao coupling to a human leukotriene B4 receptor.

21 January 2018

1 reference

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Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes

21 January 2018

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Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

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21 January 2018

Identifiers

DOI

10.1074/JBC.R500007200

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12 August 2017

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