Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis (Q36190097)

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English	Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis	scientific article

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scholarly article

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Europe PubMed Central

12 August 2017

Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis (English)

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Europe PubMed Central

12 August 2017

5

object named as

Xin Ge

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Europe PubMed Central

12 August 2017

author name string

Albert G Remacle

1

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Europe PubMed Central

12 August 2017

Piotr Cieplak

2

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Europe PubMed Central

12 August 2017

Dong Hyun Nam

3

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Europe PubMed Central

12 August 2017

Sergey A Shiryaev

4

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Europe PubMed Central

12 August 2017

Alex Y Strongin

6

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Europe PubMed Central

12 August 2017

language of work or name

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publication date

7 November 2016

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Europe PubMed Central

12 August 2017

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Europe PubMed Central

12 August 2017

8

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Europe PubMed Central

12 August 2017

2781-2799

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Europe PubMed Central

12 August 2017

2

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Europe PubMed Central

12 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5356841/fullTextXML

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Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo

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Matrix metalloproteinase-14 is a mechanically regulated activator of secreted MMPs and invasion.

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Intradomain cleavage of inhibitory prodomain is essential to protumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP) in vivo.

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Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors

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Dynamic interdomain interactions contribute to the inhibition of matrix metalloproteinases by tissue inhibitors of metalloproteinases.

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Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy

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Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis.

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Proteolytic interstitial cell migration: a five-step process.

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Direct production of functional matrix metalloproteinase--14 without refolding or activation and its application for in vitro inhibition assays.

1 reference

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22 September 2018

Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice

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22 September 2018

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22 September 2018

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1 reference

https://pubmed.ncbi.nlm.nih.gov/27835863

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based on heuristic

inferred from PubMed ID database lookup

Matrilysin is much more efficient than other matrix metalloproteinases in the proteolytic inactivation of alpha 1-antitrypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/27835863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover

1 reference

https://pubmed.ncbi.nlm.nih.gov/27835863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.18632/ONCOTARGET.13157

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

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