Strategies for MMP inhibition in cancer: innovations for the post-trial era. (Q34810420)

4 August 2017

1 reference

title

Strategies for MMP inhibition in cancer: innovations for the post-trial era. (English)

1 reference

4 August 2017

2

1 reference

4 August 2017

Christopher Mark Overall

series ordinal

1

1 reference

PubMed ID

12209155

4 August 2017

language of work or name

English

0 references

publication date

1 September 2002

1 reference

4 August 2017

Nature Reviews Cancer

1 reference

4 August 2017

2

1 reference

4 August 2017

657-672

1 reference

4 August 2017

9

1 reference

https://scigraph.springernature.com/pub.10.1038/nrc884

4 August 2017

0 references

cites work

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1 reference

Protease degradomics: a new challenge for proteomics

31 March 2020

1 reference

Matrix metalloproteinases: a tail of a frog that became a prince

31 March 2020

1 reference

Marimastat as maintenance therapy for patients with advanced gastric cancer: a randomised trial

31 March 2020

1 reference

Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

31 March 2020

1 reference

New functions for the matrix metalloproteinases in cancer progression

31 March 2020

1 reference

Functional and biochemical characterization of ADAMs and their predicted role in protein ectodomain shedding

31 March 2020

1 reference

Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains

31 March 2020

1 reference

The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3

31 March 2020

1 reference

TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)

31 March 2020

1 reference

Putting tumours in context

31 March 2020

1 reference

Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites

31 March 2020

1 reference

Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed

31 March 2020

1 reference

The proprotein convertases

31 March 2020

1 reference

Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3

31 March 2020

1 reference

Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members

31 March 2020

1 reference

The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis

31 March 2020

1 reference

Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis

31 March 2020

1 reference

Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3

31 March 2020

1 reference

Regulation of matrix metalloproteinase expression in tumor invasion.

31 March 2020

1 reference

Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change

31 March 2020

1 reference

Differential effects of transforming growth factor-beta on the expression of collagenase-1 and collagenase-3 in human fibroblasts

31 March 2020

1 reference

Repression of tissue inhibitor of matrix metalloproteinase expression by all-trans-retinoic acid in rat bone cell populations: comparison with transforming growth factor-beta 1

31 March 2020

1 reference

A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation

31 March 2020

1 reference

Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13)

31 March 2020

1 reference

Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-gamma is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1.

31 March 2020

1 reference

The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors

31 March 2020

1 reference

CIZ, a zinc finger protein that interacts with p130(cas) and activates the expression of matrix metalloproteinases

31 March 2020

1 reference

p53 down-regulates human matrix metalloproteinase-1 (Collagenase-1) gene expression

31 March 2020

1 reference

Wild type and mutant p53 differentially regulate the gene expression of human collagenase-3 (hMMP-13)

31 March 2020

1 reference

TGF-beta 1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence

31 March 2020

1 reference

A novel negative regulatory element in the human collagenase-3 proximal promoter region

31 March 2020

1 reference

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation

31 March 2020

1 reference

Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme

31 March 2020

1 reference

Substrate binding of gelatinase B induces its enzymatic activity in the presence of intact propeptide

31 March 2020

1 reference

Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation

31 March 2020

1 reference

MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover

31 March 2020

1 reference

Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme

31 March 2020

1 reference

A matrix metalloproteinase expressed on the surface of invasive tumour cells

31 March 2020

1 reference

Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway

31 March 2020

1 reference

The involvement of the fibronectin type II-like modules of human gelatinase A in cell surface localization and activation.

31 March 2020

1 reference

Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease

31 March 2020

1 reference

Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP)

31 March 2020

1 reference

Identification of the tissue inhibitor of metalloproteinases-2 (TIMP-2) binding site on the hemopexin carboxyl domain of human gelatinase A by site-directed mutagenesis. The hierarchical role in binding TIMP-2 of the unique cationic clusters of hemo

31 March 2020

1 reference

Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2.

31 March 2020

1 reference

MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells

31 March 2020

1 reference

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

31 March 2020

1 reference

Cysteine array matrix metalloproteinase (CA-MMP)/MMP-23 is a type II transmembrane matrix metalloproteinase regulated by a single cleavage for both secretion and activation

31 March 2020

1 reference

Tissue inhibitors of metalloproteinases: evolution, structure and function

31 March 2020

1 reference

Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells

31 March 2020

1 reference

Complex roles of tissue inhibitors of metalloproteinases in cancer

31 March 2020

1 reference

The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis

31 March 2020

1 reference

Tissue factor pathway inhibitor-2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis

31 March 2020

1 reference

Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor.

31 March 2020

1 reference

New functions for non-collagenous domains of human collagen type IV. Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo.

31 March 2020

1 reference

The laminin-binding domain of agrin is structurally related to N-TIMP-1

31 March 2020

1 reference

Membrane type 1 matrix metalloproteinase regulates cellular invasiveness and survival in cutaneous epidermal cells

31 March 2020

1 reference

Transcriptional suppression of matrix metalloproteinase-9 gene expression by IFN-gamma and IFN-beta: critical role of STAT-1alpha

31 March 2020

1 reference

Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark?

31 March 2020

1 reference

Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

31 March 2020

1 reference

Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts.

31 March 2020

1 reference

An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression

31 March 2020

1 reference

Malolactomycin D, a potent inhibitor of transcription controlled by the Ras responsive element, inhibits Ras-mediated transformation activity with suppression of MMP-1 and MMP-9 in NIH3T3 cells

31 March 2020

1 reference

AP-1--glucocorticoid receptor crosstalk taken to a higher level

31 March 2020

1 reference

Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B

31 March 2020

1 reference

A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflammatory cytokines

31 March 2020

1 reference

Non-steroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 expression via repression of transcription in lung cancer cells

31 March 2020

1 reference

Adenoviral delivery of p53 gene suppresses expression of collagenase-3 (MMP-13) in squamous carcinoma cells

31 March 2020

1 reference

Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN.

31 March 2020

1 reference

TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1.

31 March 2020

1 reference

Functional overlap between two classes of matrix-degrading proteases in wound healing

31 March 2020

1 reference

Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling

31 March 2020

1 reference

Local overexpression of adeno-viral IL-4 protects cartilage from metallo proteinase-induced destruction during immune complex-mediated arthritis by preventing activation of pro-MMPs

31 March 2020

1 reference

Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells

31 March 2020

1 reference

Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells

31 March 2020

1 reference

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy

31 March 2020

1 reference

Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor

31 March 2020

1 reference

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

31 March 2020

1 reference

Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity

31 March 2020

1 reference

Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

31 March 2020

1 reference

Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2

31 March 2020

1 reference

The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study

31 March 2020

1 reference

HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma

31 March 2020

1 reference

An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses

31 March 2020

1 reference

HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: a potential mechanism for protease inhibitor-induced hyperlipidemia

31 March 2020

1 reference

Development of matrix metalloproteinase inhibitors in cancer therapy.

31 March 2020

1 reference

Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial

31 March 2020

1 reference

A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer

31 March 2020

1 reference

Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment

31 March 2020

1 reference

Matrilysin in early stage intestinal tumorigenesis

31 March 2020

1 reference

Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis.

31 March 2020

1 reference

Stimulation of matrix metalloproteinase-9 expression in human fibrosarcoma cells by synthetic matrix metalloproteinase inhibitors

31 March 2020

1 reference

Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2.

31 March 2020

1 reference

METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity

31 March 2020

1 reference

Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1

31 March 2020

1 reference

Structural properties of matrix metalloproteinases

31 March 2020

1 reference

Determination of protease cleavage site motifs using mixture-based oriented peptide libraries

31 March 2020

1 reference

Tumor targeting with a selective gelatinase inhibitor

31 March 2020

1 reference

Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases

31 March 2020

1 reference

Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate

31 March 2020

1 reference

Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials

31 March 2020

1 reference

Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3.

31 March 2020

1 reference

cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone

31 March 2020

1 reference

Suppression of angiogenesis by lentiviral delivery of PEX, a noncatalytic fragment of matrix metalloproteinase 2.

31 March 2020

1 reference

Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage.

31 March 2020

1 reference

Selective transduction of protease-rich tumors by matrix-metalloproteinase-targeted retroviral vectors

31 March 2020

1 reference

Interleukin-2-collagen chimeric protein which liberates interleukin-2 upon collagenolysis

31 March 2020

1 reference

Scaling down imaging: molecular mapping of cancer in mice

31 March 2020

1 reference

The promise and peril of surrogate end points in cancer research

31 March 2020

1 reference

Collagenolytic activity in amphibian tissues: a tissue culture assay

31 March 2020

1 reference

Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix

31 March 2020

1 reference

Membrane-type matrix metalloproteinases

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Clinical studies with matrix metalloproteinase inhibitors

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC884

1 reference

PubMed ID

12209155

Dimensions Publication ID

4 August 2017

0 references

1 reference

PubMed ID

12209155