First-order rate-determining aggregation mechanism of p53 and its implications (Q36187348)

12 August 2017

First-order rate-determining aggregation mechanism of p53 and its implications (English)

1 reference

12 August 2017

2

Alan R Fersht

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12 August 2017

GuoZhen Wang

1

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PMCID

3427100

12 August 2017

language of work or name

English

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publication date

6 August 2012

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Proceedings of the National Academy of Sciences of the United States of America

12 August 2017

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12 August 2017

109

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12 August 2017

34

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12 August 2017

13590-13595

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PMCID

3427100

describes a project that uses

12 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3427100/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

1 reference

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Allele-specific p53 mutant reactivation

1 October 2017

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Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

1 October 2017

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The amyloid state of proteins in human diseases

1 October 2017

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Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

1 October 2017

1 reference

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Lumry-Eyring nucleated-polymerization model of protein aggregation kinetics. 2. Competing growth via condensation and chain polymerization

1 October 2017

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Amyloid formation by globular proteins under native conditions

1 October 2017

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Protein aggregation kinetics, mechanism, and curve-fitting: a review of the literature.

1 October 2017

1 reference

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1 October 2017

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Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

1 October 2017

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Thermodynamic stability of wild-type and mutant p53 core domain

1 October 2017

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Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53.

1 October 2017

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A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53.

2 July 2018

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The use of 4-(2-pyridylazo)resorcinol in studies of zinc release from Escherichia coli aspartate transcarbamoylase.

2 July 2018

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Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.

2 July 2018

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Folding of tetrameric p53: oligomerization and tumorigenic mutations induce misfolding and loss of function

21 January 2018

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Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain

21 January 2018

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A Lumry-Eyring nucleated polymerization model of protein aggregation kinetics: 1. Aggregation with pre-equilibrated unfolding.

21 January 2018

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Electrocatalytic monitoring of metal binding and mutation-induced conformational changes in p53 at picomole level.

21 January 2018

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Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1073/PNAS.1211557109

1 reference

12 August 2017

0 references

1 reference

12 August 2017

1 reference

PMCID

3427100