Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53. (Q41768808)

9 October 2017

Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53. (English)

1 reference

9 October 2017

3

Alan R Fersht

1 reference

9 October 2017

Sridharan Rajagopalan

series ordinal

1

1 reference

PMCID

3064802

9 October 2017

Fang Huang

series ordinal

2

1 reference

9 October 2017

18 November 2010

1 reference

9 October 2017

Nucleic Acids Research

1 reference

9 October 2017

39

1 reference

9 October 2017

2294-2303

1 reference

9 October 2017

6

1 reference

Creative Commons Attribution-NonCommercial 2.5 Generic

9 October 2017

start time

7 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

1 reference

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Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer

6 June 2018

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Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms

6 June 2018

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Direct observation of ultrafast folding and denatured state dynamics in single protein molecules

6 June 2018

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Ultraslow oligomerization equilibria of p53 and its implications

6 June 2018

1 reference

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Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics

6 June 2018

1 reference

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6 June 2018

Modes of p53 regulation

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Blinded by the Light: The Growing Complexity of p53

6 June 2018

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Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers

6 June 2018

1 reference

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p53 Oligomerization is essential for its C-terminal lysine acetylation

6 June 2018

1 reference

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14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers

6 June 2018

1 reference

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Probing polyproline structure and dynamics by photoinduced electron transfer provides evidence for deviations from a regular polyproline type II helix.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex

6 June 2018

1 reference

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

6 June 2018

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Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

6 June 2018

1 reference

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Core domain interactions in full-length p53 in solution

6 June 2018

1 reference

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Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor

6 June 2018

1 reference

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Fluorescence correlation spectroscopy: a new tool for quantification of molecular interactions

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Fluorescence correlation spectroscopy and its potential for intracellular applications

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect

6 June 2018

1 reference

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Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Inhibition of p53 transcriptional activity by the S100B calcium-binding protein.

6 June 2018

1 reference

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Structure and functionality of a designed p53 dimer

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Resolution of fluorescence correlation measurements

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

How p53 binds DNA as a tetramer

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

A previously undescribed mutation within the tetramerisation domain of TP53 in a family with Li-Fraumeni syndrome.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

p53 oligomerization and DNA looping are linked with transcriptional activation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Fluorescence correlations, single molecule detection and large number screening. Applications in biotechnology

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Oligomerization of p53 upon cooperative DNA binding: towards a structural understanding of p53 function.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Comparison and accuracy of methods to determine the confocal volume for quantitative fluorescence correlation spectroscopy

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Natural selection for kinetic stability is a likely origin of correlations between mutational effects on protein energetics and frequencies of amino acid occurrences in sequence alignments.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Cooperative binding of tetrameric p53 to DNA.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Kinetic Instability of p53 Core Domain Mutants

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064802

Fluorescence correlation spectroscopy

2 December 2018

1 reference

12 December 2020

Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53

1 reference

12 December 2020

Mechanism of folding and assembly of a small tetrameric protein domain from tumor suppressor p53

1 reference

12 December 2020

Fluorescence correlation spectrometry of the interaction kinetics of tetramethylrhodamin alpha-bungarotoxin with Torpedo californica acetylcholine receptor

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKQ800

1 reference

9 October 2017

1 reference

9 October 2017

1 reference

PMCID

3064802