Human polycystin-2 transgene dose-dependently rescues ADPKD phenotypes in Pkd2 mutant mice (Q36167611)

12 August 2017

Human polycystin-2 transgene dose-dependently rescues ADPKD phenotypes in Pkd2 mutant mice (English)

1 reference

12 August 2017

7

1 reference

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4 June 2020

author name string

Ao Li

1

1 reference

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4 June 2020

Xin Tian

2

1 reference

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4 June 2020

Xiaoli Zhang

3

1 reference

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4 June 2020

Shunwei Huang

4

1 reference

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4 June 2020

Yujie Ma

5

1 reference

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4 June 2020

Dianqing Wu

6

1 reference

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4 June 2020

Stefan Somlo

8

1 reference

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4 June 2020

Guanqing Wu

9

1 reference

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4 June 2020

language of work or name

English

0 references

publication date

1 October 2015

1 reference

The American Journal of Pathology

12 August 2017

1 reference

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4 June 2020

volume

185

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4 June 2020

issue

10

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4 June 2020

page(s)

2843-2860

1 reference

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Altered trafficking and stability of polycystins underlie polycystic kidney disease

4 June 2020

cites work

1 reference

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Cyst formation following disruption of intracellular calcium signaling

1 October 2017

1 reference

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Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease

1 October 2017

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Review of tolvaptan for autosomal dominant polycystic kidney disease.

1 October 2017

1 reference

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Polycystin-1: a master regulator of intersecting cystic pathways

1 October 2017

1 reference

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A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease.

1 October 2017

1 reference

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Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease

1 October 2017

1 reference

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Multidrug therapy for polycystic kidney disease: a review and perspective

1 October 2017

1 reference

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Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity

1 October 2017

1 reference

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Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2

1 October 2017

1 reference

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The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism

1 October 2017

1 reference

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Macrophages promote cyst growth in polycystic kidney disease

1 October 2017

1 reference

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A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

1 October 2017

1 reference

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Polycystic kidney disease: pathogenesis and potential therapies

1 October 2017

1 reference

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The cell biology of polycystic kidney disease

1 October 2017

1 reference

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Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

Molecular advances in autosomal dominant polycystic kidney disease

1 October 2017

1 reference

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Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice.

1 October 2017

1 reference

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Imaging for the prognosis of autosomal dominant polycystic kidney disease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1.

1 October 2017

1 reference

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Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

Autosomal dominant polycystic kidney disease: the last 3 years

1 October 2017

1 reference

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Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks

1 October 2017

1 reference

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Renal injury is a third hit promoting rapid development of adult polycystic kidney disease

1 October 2017

1 reference

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Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

1 October 2017

1 reference

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Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

1 October 2017

1 reference

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Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function

1 October 2017

1 reference

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A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1

1 October 2017

1 reference

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Wnt signaling in polycystic kidney disease

1 October 2017

1 reference

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The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

1 October 2017

1 reference

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PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells

1 October 2017

1 reference

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Two populations of node monocilia initiate left-right asymmetry in the mouse

1 October 2017

1 reference

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Genetics and pathogenesis of polycystic kidney disease.

1 October 2017

1 reference

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The ion channel polycystin-2 is required for left-right axis determination in mice

1 October 2017

1 reference

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Thoracic aortic dissection in a patient with autosomal dominant polycystic kidney disease.

1 October 2017

1 reference

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Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

Cardiac defects and renal failure in mice with targeted mutations in Pkd2

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

A rapid and non-invasive selection of transgenic embryos before implantation using green fluorescent protein (GFP).

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

Overexpression of PKD1 causes polycystic kidney disease

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

Molecular cloning, cDNA sequence analysis, and chromosomal localization of mouse Pkd2.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

mTOR inhibitors in polycystic kidney disease.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

Inhibition of tubule-cell proliferation to prevent cyst formation: a new avenue to treat ADPKD?

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

Trans-heterozygous Pkd1 and Pkd2 mutations modify expression of polycystic kidney disease.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

Pathogenesis of autosomal dominant polycystic kidney disease: role of apoptosis

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

Ultrasonographic study of pancreatic cysts in autosomal dominant polycystic kidney disease.

23 September 2018

1 reference

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The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors

23 September 2018

1 reference

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Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissues

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607765

5 December 2018

1 reference

12 December 2020

Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort

1 reference

12 December 2020

Overexpression of PKD2 in the mouse is associated with renal tubulopathy

1 reference

12 December 2020

Screening for intracranial aneurysms in ADPKD

1 reference

12 December 2020

Polycystic kidney disease: Polycystin-1 and polycystin-2--it's complicated

1 reference

12 December 2020

Proliferative activity of cyst epithelium in human renal cystic diseases

1 reference

12 December 2020

Somatic inactivation of Pkd2 results in polycystic kidney disease

1 reference

12 December 2020

Liver cysts in patients with autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Cyst formation and growth in autosomal dominant polycystic kidney disease

1 reference

12 December 2020

10.1016/J.AJPATH.2015.06.014

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26435415%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26435415%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

PubMed publication ID

26435415

1 reference