A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease. (Q37411615)

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scientific article published on 26 September 2013

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English	A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease.	scientific article published on 26 September 2013

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scholarly article

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23 February 2020

A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease (English)

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23 February 2020

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autosomal dominant polycystic kidney disease

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autosomal dominant polycystic kidney

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inferred from title

3

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Marc K. Halushka

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author name string

Dongyan Liu

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Connie J Wang

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Jie Ni

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Jennifer P Habashi

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Javid Moslehi

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Djahida Bedja

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Kathleen L Gabrielson

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Hangxue Xu

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Feng Qian

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David Huso

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Harry C Dietz

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Gregory G Germino

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Terry Watnick

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publication date

26 September 2013

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Journal of the American Society of Nephrology

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25

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23 February 2020

1

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81-91

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11 June 2022

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Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm

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A case of severe aortic valve regurgitation caused by an ascending aortic aneurysm in a young patient with autosomal dominant polycystic kidney disease and normal renal function.

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Extended follow-up of unruptured intracranial aneurysms detected by presymptomatic screening in patients with autosomal dominant polycystic kidney disease

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Hypertension in autosomal dominant polycystic kidney disease

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6 September 2017

Molecular advances in autosomal dominant polycystic kidney disease

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6 September 2017

Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks

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6 September 2017

Polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

6 September 2017

Marfan syndrome: from molecular pathogenesis to clinical treatment

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6 September 2017

Abdominal visceral findings in patients with Marfan syndrome

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6 September 2017

Developmental basis of vascular smooth muscle diversity

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6 September 2017

Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome

1 reference

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6 September 2017

A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2

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TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome

1 reference

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6 September 2017

Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome

1 reference

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6 September 2017

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

1 reference

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6 September 2017

Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

6 September 2017

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

6 September 2017

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure

1 reference

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6 September 2017

Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene

1 reference

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6 September 2017

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

6 September 2017

Vascular expression of polycystin-2.

1 reference

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6 September 2017

Angiotensin II upregulates transforming growth factor-beta type I receptor on rat vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

6 September 2017

Polycystin 1 is required for the structural integrity of blood vessels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

6 September 2017

Mutation detection of PKD1 identifies a novel mutation common to three families with aneurysms and/or very-early-onset disease

1 reference

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6 September 2017

PKD1 interacts with PKD2 through a probable coiled-coil domain

1 reference

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6 September 2017

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

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6 September 2017

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

1 reference

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6 September 2017

Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells

1 reference

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28 September 2017

Cardiovascular Abnormalities Associated with Adult Polycystic Kidney Disease

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26 June 2018

Marfan syndrome and cystic kidneys of the adult type

1 reference

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26 June 2018

Dissecting aneurysm in a patient with autosomal dominant polycystic kidney disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

2 September 2018

Parsing aortic aneurysms: more surprises

1 reference

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2 September 2018

Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

2 September 2018

Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

2 September 2018

Histopathologic findings in ascending aortas from individuals with Loeys-Dietz syndrome (LDS).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

2 September 2018

Cardiac neural crest is necessary for normal addition of the myocardium to the arterial pole from the secondary heart field.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

2 September 2018

Bilateral popliteal aneurysms complicating adult polycystic kidney disease in a patient with a marfanoid habitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

2 September 2018

Association of mutation position in polycystic kidney disease 1 (PKD1) gene and development of a vascular phenotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

2 September 2018

Vascular expression of polycystin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

2 September 2018

Aneurysm of the splenic artery in a patient with autosomal dominant polycystic kidney disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

2 September 2018

Smooth muscle lineage diversity in the chick embryo. Two types of aortic smooth muscle cell differ in growth and receptor-mediated transcriptional responses to transforming growth factor-beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

2 September 2018

Occult intracranial aneurysms in polycystic kidney disease: screening with MR angiography.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871766

2 September 2018

A kindred exhibiting cosegregation of an overlap connective tissue disorder and the chromosome 16 linked form of autosomal dominant polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the polycystins in aortic vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polycystin-1 and -2 Dosage Regulates Pressure Sensing

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extrarenal manifestations of autosomal dominant polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Polycystic renal disease in the adult associated with an incomplete form of Marfan's syndrome (author's transl)]

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracranial aneurysms in autosomal dominant polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Value of magnetic resonance angiography for the detection of intracranial aneurysms in autosomal dominant polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The vasculopathy of autosomal dominant polycystic kidney disease: insights from animal models

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous artery dissection: is it part of the spectrum of autosomal dominant polycystic kidney disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenic sequence for dissecting aneurysm formation in a hypomorphic polycystic kidney disease 1 mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of vascular smooth muscle cells from a single murine aorta

1 reference

https://pubmed.ncbi.nlm.nih.gov/24071006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1681/ASN.2012050486

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23 February 2020

1 reference

Europe PubMed Central

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23 February 2020

1 reference

Europe PubMed Central

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23 February 2020

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