cGMP-dependent protein kinases in drug discovery (Q36127830)

12 August 2017

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title

cGMP-dependent protein kinases in drug discovery (English)

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12 August 2017

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Jens Schlossmann

1

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PubMed ID

15894227

12 August 2017

Franz Hofmann

series ordinal

2

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12 August 2017

1 May 2005

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12 August 2017

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12 August 2017

10

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12 August 2017

627-634

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12 August 2017

9

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Role of mitochondrial aldehyde dehydrogenase in nitroglycerin-induced vasodilation of coronary and systemic vessels: an intact canine model

12 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Identification of the enzymatic mechanism of nitroglycerin bioactivation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

DA-8159, a potent cGMP phosphodiesterase inhibitor, attenuates monocrotaline-induced pulmonary hypertension in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Viagra (sildenafil citrate) and ophthalmology

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Overview of phosphodiesterase 5 inhibition in erectile dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Regulation of nitric oxide-sensitive guanylyl cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: synergism of nitric oxide and YC-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

BAY 41-2272: a stimulator of soluble guanylyl cyclase induces nitric oxide-dependent penile erection in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Inhibition of phosphodiesterase type 5 by the activator of nitric oxide-sensitive guanylyl cyclase BAY 41-2272.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Nitric oxide-sensitive soluble guanylyl cyclase activity is preserved in internal mammary artery of type 2 diabetic patients

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

The biology of cyclic GMP-dependent protein kinases

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Distribution of IRAG and cGKI-isoforms in murine tissues

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Insights into cGMP signalling derived from cGMP kinase knockout mice

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Signaling through NO and cGMP‐dependent protein kinases

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Mechanisms of NO/cGMP-dependent vasorelaxation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Serine phosphorylation negatively regulates RhoA in vivo.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

In vivo reconstitution of the negative feedback in nitric oxide/cGMP signaling: role of phosphodiesterase type 5 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Regulation of canonical transient receptor potential isoform 3 (TRPC3) channel by protein kinase G.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Defective smooth muscle regulation in cGMP kinase I-deficient mice

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Impaired relaxation of stomach smooth muscle in mice lacking cyclic GMP-dependent protein kinase I

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Functional characteristics of urinary tract smooth muscles in mice lacking cGMP protein kinase type I

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Increased adhesion and aggregation of platelets lacking cyclic guanosine 3',5'-monophosphate kinase I.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

A stimulatory role for cGMP-dependent protein kinase in platelet activation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

cGMP inhibits IP3-induced Ca2+ release in intact rat megakaryocytes via cGMP- and cAMP-dependent protein kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization. Independent modulation of Tp alpha signaling by nitric oxide and prostacyclin.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Enhanced in vivo platelet adhesion in vasodilator-stimulated phosphoprotein (VASP)-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Heat shock protein 27 is a substrate of cGMP-dependent protein kinase in intact human platelets: phosphorylation-induced actin polymerization caused by HSP27 mutants

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Function of cGMP-dependent protein kinases in the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Phosphorylation of type-1 inositol 1,4,5-trisphosphate receptors by cyclic nucleotide-dependent protein kinases: a mutational analysis of the functionally important sites in the S2+ and S2- splice variants

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Thr123 of rat G-substrate contributes to its action as a protein phosphatase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Inhibition of cyclic guanosine 5'-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl- channel activation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

cGMP-dependent protein kinase II modulates mPer1 and mPer2 gene induction and influences phase shifts of the circadian clock

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Protein kinase G type II is required for night-to-day progression of the mammalian circadian clock.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Cyclic nucleotide analogs as biochemical tools and prospective drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Substituted cGMP analogs can act as selective agonists of the rod photoreceptor cGMP-gated cation channel.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Delineation of selective cyclic GMP-dependent protein kinase Ialpha substrate and inhibitor peptides based on combinatorial peptide libraries on paper

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Ialpha inhibit NO-induced cerebral dilation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Inhibition of cGMP-dependent protein kinase by the cell-permeable peptide DT-2 reveals a novel mechanism of vasoregulation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

A cGMP-dependent protein kinase assay for high throughput screening based on time-resolved fluorescence resonance energy transfer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Analogs of cyclic nucleotides in rat liver preservation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

The nitric oxide/cyclic GMP pathway in organ transplantation: critical role in successful lung preservation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

8-Br-cGMP is superior to prostaglandin E1 for lung preservation.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

A neuronal isoform of protein kinase G couples mitogen-activated protein kinase nuclear import to axotomy-induced long-term hyperexcitability in Aplysia sensory neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Activity of cGMP-dependent protein kinase (PKG) affects sucrose responsiveness and habituation in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903406-9

7 January 2021

10.1016/S1359-6446(05)03406-9

Identifiers

DOI

1 reference

12 August 2017

1 reference

PubMed ID

15894227