Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3 (Q36126184)

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9 February 2020

title

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3 (English)

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9 February 2020

2

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9 February 2020

Andreas Brust

3

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9 February 2020

Glenn F King

5

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9 February 2020

Lachlan D. Rash

6

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9 February 2020

4

Paul F Alewood

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9 February 2020

author name string

Jonas E Jensen

1

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9 February 2020

publication date

16 July 2012

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9 February 2020

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9 February 2020

volume

10

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9 February 2020

issue

7

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9 February 2020

page(s)

1511-1527

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Creative Commons Attribution 4.0 International

9 February 2020

copyright license

start time

16 July 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons

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Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3.

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Expression in Pichia pastoris and characterization of APETx2, a specific inhibitor of acid sensing ion channel 3.

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Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor.

21 January 2018

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21 January 2018

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12 December 2020

Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter

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12 December 2020

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

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Identifiers

DOI

10.3390/MD10071511

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9 February 2020

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9 February 2020

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