Venoms as a platform for human drugs: translating toxins into therapeutics (Q37937049)

25 August 2017

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title

Venoms as a platform for human drugs: translating toxins into therapeutics (English)

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25 August 2017

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1

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PubMed ID

21939428

25 August 2017

language of work or name

English

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publication date

23 September 2011

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Expert Opinion on Biological Therapy

25 August 2017

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25 August 2017

11

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25 August 2017

1469-1484

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25 August 2017

11

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Lessons from 60 years of pharmaceutical innovation

25 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

The productivity crisis in pharmaceutical R&D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Natural products and combinatorial chemistry: back to the future

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Chemistry. The renaissance of natural products as drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Natural products as sources of new drugs over the last 25 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Lessons from natural molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

The evolving role of natural products in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Drug discovery beyond the 'rule-of-five'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

A case of zootherapy with the tarantula Brachypelma vagans Ausserer, 1875 in traditional medicine of the Chol Mayan ethnic group in Mexico

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Alpha-cobratoxin as a possible therapy for multiple sclerosis: a review of the literature leading to its development for this application

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

History of the design of captopril and related inhibitors of angiotensin converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

The discovery of captopril: from large animals to small molecules

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Venomics: a new paradigm for natural products-based drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Therapeutic potential of venom peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Targeting ionotropic receptors with polyamine-containing toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

NMR-spectroscopic screening of spider venom reveals sulfated nucleosides as major components for the brown recluse and related species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Venomics: unravelling the complexity of animal venoms with mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Venomics as a drug discovery platform.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Molecular diversity of spider venom.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Combinatorial peptide libraries in drug design: lessons from venomous cone snails

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Were arachnids the first to use combinatorial peptide libraries?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

From genome to "venome": molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Approaching the golden age of natural product pharmaceuticals from venom libraries: an overview of toxins and toxin-derivatives currently involved in therapeutic or diagnostic applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Venom landscapes: mining the complexity of spider venoms via a combined cDNA and mass spectrometric approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Characterization of peptide components in the venom of the scorpion Liocheles australasiae (Hemiscorpiidae).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Scorpion toxins specific for Na+-channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Conus venoms - a rich source of peptide-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Spider venoms: a rich source of acylpolyamines and peptides as new leads for CNS drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Peptide toxins that selectively target insect Na(V) and Ca(V) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

alpha-Conotoxins as selective probes for nicotinic acetylcholine receptor subclasses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Diversity of folds in animal toxins acting on ion channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

A common structural motif incorporating a cystine knot and a triple-stranded beta-sheet in toxic and inhibitory polypeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Spider-venom peptides as therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Bioactive cystine knot proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Small peptides, big world: biotechnological potential in neglected bioactive peptides from arthropod venoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Mass spectrometry strategies for venom mapping and peptide sequencing from crude venoms: case applications with single arthropod specimen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

A rational nomenclature for naming peptide toxins from spiders and other venomous animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Proteome and peptidome profiling of spider venoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Australian funnel-web spiders: master insecticide chemists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Peptide leads new class of chronic pain drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Orally active acaricidal peptide toxins from spider venom.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Spider venom toxin protects plants from insect attack.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Novel insecticidal peptides from Tegenaria agrestis spider venom may have a direct effect on the insect central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Mode of action of atracotoxin at central and peripheral synapses of insects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Maurocalcine as a non toxic drug carrier overcomes doxorubicin resistance in the cancer cell line MDA-MB 231

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Alpha-conotoxin Vc1.1 alleviates neuropathic pain and accelerates functional recovery of injured neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

21 January 2018

Selenopeptide chemistry.

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Direct visualization of disulfide bonds through diselenide proxies using 77Se NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Isosteric replacement of sulfur with other chalcogens in peptides and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, omega-selenoconotoxin GVIA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Mu-conotoxins as leads in the development of new analgesics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Strategies to improve plasma half life time of peptide and protein drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Therapeutic peptides: technological advances driving peptides into development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Therapeutic application of peptides and proteins: parenteral forever?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Synthetic therapeutic peptides: science and market

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Chemical modification of conotoxins to improve stability and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

An SCN9A channelopathy causes congenital inability to experience pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

21 January 2018

Breaching the barrier.

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Eptifibatide: a potent inhibitor of the platelet receptor integrin glycoprotein IIb/IIIa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Tirofiban in acute coronary syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Ziconotide: neuronal calcium channel blocker for treating severe chronic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Positron emission tomography imaging of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

CNSB004 (Leconotide) causes antihyperalgesia without side effects when given intravenously: a comparison with ziconotide in a rat model of diabetic neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Tumor paint: a chlorotoxin:Cy5.5 bioconjugate for intraoperative visualization of cancer foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Annexin A2 is a molecular target for TM601, a peptide with tumor-targeting and anti-angiogenic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Pharmacodynamics of a novel designer natriuretic peptide, CD-NP, in a first-in-human clinical trial in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Novel natriuretic peptides from the venom of the inland taipan (Oxyuranus microlepidotus): isolation, chemical and biological characterisation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

A tarantula peptide against pain via ASIC1a channels and opioid mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

ASIC3, a sensor of acidic and primary inflammatory pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

Vicrostatin - an anti-invasive multi-integrin targeting chimeric disintegrin with tumor anti-angiogenic and pro-apoptotic activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.621940

10.1517/14712598.2011.621940

21 January 2018

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

21939428