Natural products to drugs: natural product derived compounds in clinical trials (Q36087066)

12 August 2017

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title

Natural products to drugs: natural product derived compounds in clinical trials (English)

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12 August 2017

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Mark S Butler

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publication date

8 March 2005

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12 August 2017

Natural Product Reports

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12 August 2017

22

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12 August 2017

162-195

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12 August 2017

2

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Advanced preclinical and clinical trials of natural products and related compounds from marine sources

12 August 2017

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Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity

21 January 2018

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Macrolactam immunomodulators (tacrolimus and pimecrolimus): new horizons in the topical treatment of inflammatory skin diseases

21 January 2018

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From natural products to clinically useful antifungals

21 January 2018

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Uptake and intracellular distribution of amrubicin, a novel 9-amino-anthracycline, and its active metabolite amrubicinol in P388 murine leukemia cells.

21 January 2018

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Advances in the discovery of novel antibacterial agents during the year 2002.

21 January 2018

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The discovery and development of modified penicillin- and cephalosporin-derived beta-lactamase inhibitors

21 January 2018

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The art of fusion: from penams and cephems to penems

21 January 2018

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Comparative in vitro activity of S-4661, a new parenteral carbapenem, and other antimicrobial agents against respiratory pathogens

21 January 2018

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21 January 2018

Glycopeptide derivatives

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Valine influences production and complex composition of glycopeptide antibiotic A40926 in fermentations of Nonomuraea sp. ATCC 39727.

21 January 2018

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Hydrophobic vancomycin derivatives with improved ADME properties: discovery of telavancin (TD-6424).

21 January 2018

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Inhibition of bacterial protein synthesis by elongation-factor-Tu-binding antibiotics MDL 62,879 and efrotomycin

21 January 2018

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Synthesis and biological activity of 3'-hydroxy-5'-aminobenzoxazinorifamycin derivatives

21 January 2018

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Comparative pharmacokinetics of three preparations of the new antifungal SPK-843.

21 January 2018

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Trial of oral fumagillin for the treatment of intestinal microsporidiosis in patients with HIV infection. ANRS 054 Study Group. Agence Nationale de Recherche sur le SIDA.

21 January 2018

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Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C.

21 January 2018

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Iminosugars as possible broad spectrum anti hepatitis virus agents: the glucovirs and alkovirs

21 January 2018

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Clinical trials of neuroprotection for Parkinson's disease

21 January 2018

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New trends in the design of drugs against Alzheimer's disease

21 January 2018

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A review of neuroprotective agents

21 January 2018

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Drugs from the sea: conopeptides as potential therapeutics

21 January 2018

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Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347.

21 January 2018

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ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium

21 January 2018

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Future immunosuppressive agents in solid-organ transplantation.

21 January 2018

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New trends in immunosuppression

21 January 2018

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Novel insights and therapeutical applications in the field of inhibitors of COX-2.

21 January 2018

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The proteolytic action of Arvin on human fibrinogen

21 January 2018

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Critical care assessment and management of acute ischemic stroke

21 January 2018

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A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo.

21 January 2018

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A novel combretastatin A-4 derivative, AC-7700, shows marked antitumor activity against advanced solid tumors and orthotopically transplanted tumors.

21 January 2018

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PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis

21 January 2018

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Non-camptothecin DNA topoisomerase I inhibitors in cancer therapy

21 January 2018

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Myxobacterial epothilones and tubulysins as promising anticancer agents

21 January 2018

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Characterization of the interaction of TZT-1027, a potent antitumor agent, with tubulin.

21 January 2018

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Identification of an antimalarial synthetic trioxolane drug development candidate

21 January 2018

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COCI

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE02779

Artemisinins target the SERCA of Plasmodium falciparum

15 July 2023

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COCI

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE01813

Halichondrins - antitumor polyether macrolides from a marine sponge

15 July 2023

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20 August 2023

https://opencitations.net/index/coci/api/v1/citations/10.1351/PAC198658050701

Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

1 reference

9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/ANIE.199615671

Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.49.560

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.47.301

Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.47.208

Novel cholecystokinin antagonists from Aspergillus alliaceus. II. Structure determination of asperlicins B, C, D, and E

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.41.878

Novel cholecystokinin antagonists from Aspergillus alliaceus. I. Fermentation, isolation, and biological properties

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.41.875

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.42.571

Characterization of the antifungal and antiprotozoal antibiotic partricin and structural studies on partricins A and B

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.35.997

Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Fermentation, isolation and biological properties.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.38.1633

A-16686, a new antibiotic from Actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristics

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.37.309

Ramoplanin (A-16686), a new glycolipodepsipeptide antibiotic. III. Structure elucidation

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.42.254

Cispentacin, a new antifungal antibiotic. II. In vitro and in vivo antifungal activities

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.42.1756

The structure of vacidin A, an aromatic heptaene macrolide antibiotic. I. Complete assignment of the 1H NMR spectrum and geometry of the polyene chromophore

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.42.1631

Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.40.1086

The structures of the novel protein kinase C inhibitors K-252a, b, c and d

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.39.1072

K-252a, a potent inhibitor of protein kinase C from microbial origin

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.39.1059

Characterization of the interaction of ingenol 3-angelate with protein kinase C.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1158/0008-5472.CAN-03-3403

The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1139/V86-137

Identifiers

DOI

10.1039/B402985M

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12 August 2017

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PubMed ID

15806196