Characterization of the interaction of TZT-1027, a potent antitumor agent, with tubulin. (Q54974194)

14 June 2018

title

Characterization of the interaction of TZT-1027, a potent antitumor agent, with tubulin. (English)

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14 June 2018

author name string

T Natsume

1

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14 June 2018

J Watanabe

2

1 reference

14 June 2018

S Tamaoki

3

1 reference

14 June 2018

N Fujio

4

1 reference

14 June 2018

K Miyasaka

5

1 reference

14 June 2018

M Kobayashi

6

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14 June 2018

publication date

1 July 2000

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14 June 2018

number of pages

11

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Japanese Journal of Cancer Research

inferred from page(s)

published in

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14 June 2018

volume

91

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14 June 2018

issue

7

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14 June 2018

page(s)

737-747

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14 June 2018

The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells

cites work

1 reference

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Epothilone B stabilizes microtubuli of macrophages like taxol without showing taxol-like endotoxin activity

14 June 2018

1 reference

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Antitumor activity of TZT-1027, a novel dolastatin 10 derivative.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Microtubule-based motor proteins: new targets for enhancing drug delivery?

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Pilot study of vinorelbine (Navelbine) and paclitaxel (Taxol) in patients with refractory breast cancer and lung cancer.

14 June 2018

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LU103793 (NSC D-669356): a synthetic peptide that interacts with microtubules and inhibits mitosis.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Taxol binds to cellular microtubules

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Taxol binds to polymerized tubulin in vitro

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

A rapid method for quantitative determination of microtubule protein using DEAE-cellulose filters.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Microtubule Assembly in the Absence of Added Nucleotides

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Rhizoxin binding to tubulin at the maytansine-binding site.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Interaction of phomopsin A with porcine brain tubulin. Inhibition of tubulin polymerization and binding at a rhizoxin binding site.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Interaction of dolastatin 10 with bovine brain tubulin

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Inhibition of tubulin-microtubule polymerization by drugs of the Vinca alkaloid class

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Binding of maytansine to rat brain tubulin

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Action of the vinca alkaloids vincristine, vinblastine, and desacetyl vinblastine amide on microtubules in vitro

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Calcium-sensitivity of the microtubule reassembly system. Difference between crude brain extract and purified microtubular proteins

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Promotion of microtubule assembly in vitro by taxol

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

Preparation of tubulin from brain.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926414

In vitro synergy of paclitaxel (Taxol) and vinorelbine (navelbine) against human melanoma cell lines

13 August 2018

1 reference

12 December 2020

Interaction of marine toxin dolastatin 10 with porcine brain tubulin: competitive inhibition of rhizoxin and phomopsin A binding

1 reference

12 December 2020

Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain

1 reference

12 December 2020

Photoaffinity labeling of tubulin subunits with a photoactive analogue of vinblastine

1 reference

12 December 2020

Synthesis and antitumor activity of novel dolastatin 10 analogs

1 reference

12 December 2020

Taxol and vinorelbine: a new active combination for disseminated malignant melanoma

1 reference

12 December 2020

Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions

1 reference

12 December 2020

Combined antimicrotubule activity of estramustine and taxol in human prostatic carcinoma cell lines

1 reference

12 December 2020

Glutamate-induced polymerization of tubulin: Characteristics of the reaction and application to the large-scale purification of tubulin

1 reference

12 December 2020

Maytansine inhibits nucleotide binding at the exchangeable site of tubulin.

1 reference

12 December 2020

Vinorelbine tartrate and paclitaxel combinations: enhanced activity against in vivo P388 murine leukemia cells

1 reference

12 December 2020

10.1111/J.1349-7006.2000.TB01007.X

Identifiers

DOI

1 reference

14 June 2018

PMCID

5926414

1 reference

14 June 2018

PubMed ID

10920282

1 reference

14 June 2018