A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice (Q36075303)

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English	A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

12 August 2017

A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice (English)

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Europe PubMed Central

PMC publication ID

12 August 2017

immunoproteasome

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based on heuristic

inferred from title

author name string

M Wehenkel

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

J-O Ban

2

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Y-K Ho

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

K C Carmony

4

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

J T Hong

5

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Europe PubMed Central

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12 August 2017

K B Kim

6

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Europe PubMed Central

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12 August 2017

language of work or name

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publication date

7 June 2012

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Europe PubMed Central

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12 August 2017

British Journal of Cancer

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Europe PubMed Central

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12 August 2017

107

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Europe PubMed Central

PMC publication ID

12 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

53-62

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

https://scigraph.springernature.com/pub.10.1038/bjc.2012.243

0 references

Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

Second generation proteasome inhibitors: carfilzomib and immunoproteasome-specific inhibitors (IPSIs).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

Bortezomib sensitizes human esophageal squamous cell carcinoma cells to TRAIL-mediated apoptosis via activation of both extrinsic and intrinsic apoptosis pathways

1 reference

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2 October 2017

Proteasome inhibitors: recent advances and new perspectives in medicinal chemistry

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

No Splicing, no dicing: non-proteolytic roles of the ubiquitin-proteasome system in transcription

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2 October 2017

Obovatol enhances docetaxel-induced prostate and colon cancer cell death through inactivation of nuclear transcription factor-kappaB.

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2 October 2017

Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome

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2 October 2017

NFkappaB signaling in carcinogenesis and as a potential molecular target for cancer therapy

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2 October 2017

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

1 reference

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2 October 2017

Bortezomib-mediated inhibition of steroid receptor coactivator-3 degradation leads to activated Akt.

1 reference

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2 October 2017

Bortezomib-induced peripheral neuropathy in multiple myeloma: a comprehensive review of the literature

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2 October 2017

Proteasome modulators: essential chemical genetic tools for understanding human diseases

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2 October 2017

The role of the NFkappaB signalling pathway in cancer

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2 October 2017

Regulation of CD8+ T cell development by thymus-specific proteasomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

LMP2-specific inhibitors: chemical genetic tools for proteasome biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

A novel proteasome inhibitor NPI-0052 as an anticancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

Immunoproteasomes: regulating the regulator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

Targeting BCL-2 overexpression in various human malignancies through NF-kappaB inhibition by the proteasome inhibitor bortezomib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

The development of proteasome inhibitors as anticancer drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

Proteasome inhibitor PS-341 down-regulates prostate-specific antigen (PSA) and induces growth arrest and apoptosis of androgen-dependent human prostate cancer LNCaP cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

Rationale for the treatment of solid tumors with the proteasome inhibitor bortezomib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

Antigen processing by the proteasome

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

Association of immunoproteasomes with the endoplasmic reticulum

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

2 October 2017

Aberrant rel/nfkb genes and activity in human cancer

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2 October 2017

Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

11 July 2018

Proteasomes in immune cells: more than peptide producers?

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

11 July 2018

The biological functions of NF-kappaB1 (p50) and its potential as an anti-cancer target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

11 July 2018

Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

11 July 2018

Prevention of experimental colitis by a selective inhibitor of the immunoproteasome.

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2012.243

21 January 2018

Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome

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https://api.crossref.org/works/10.1038%2FBJC.2012.243

21 January 2018

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2012.243

21 January 2018

Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2012.243

21 January 2018

Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis

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21 January 2018

Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis

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https://api.crossref.org/works/10.1038%2FBJC.2012.243

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Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology.

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https://api.crossref.org/works/10.1038%2FBJC.2012.243

21 January 2018

Eponemycin analogues: syntheses and use as probes of angiogenesis.

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21 January 2018

Drug interactions between the proteasome inhibitor bortezomib and cytotoxic chemotherapy, tumor necrosis factor (TNF) alpha, and TNF-related apoptosis-inducing ligand in prostate cancer.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

23 September 2018

Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines.

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23 September 2018

LMP2 expression and proteasome activity in NOD mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389428

21 October 2018

Reply to 'LMP2 expression and proteasome activity in NOD mice'

1 reference

https://pubmed.ncbi.nlm.nih.gov/22677907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I/II study of bortezomib plus docetaxel in patients with advanced androgen-independent prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22677907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/22677907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome inhibitor drugs on the rise

1 reference

https://pubmed.ncbi.nlm.nih.gov/22677907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome and transcription: a destroyer goes into construction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22677907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LMP2 expression and proteasome activity in NOD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22677907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced intestinal expression of the proteasome subunit low molecular mass polypeptide 2 in patients with inflammatory bowel disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22677907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MHC-encoded proteasome subunits LMP2 and LMP7 are not required for efficient antigen presentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22677907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/BJC.2012.243

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Dimensions Publication ID

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

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