Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development (Q36070046)

12 August 2017

Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development (English)

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Alejandra González-Loyola

12 August 2017

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1

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31 May 2020

Marianna Trakala

3

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Alba De Martino Rodriguez

31 May 2020

8

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31 May 2020

Guillermo de Cárcer

10

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31 May 2020

Ignacio Pérez de Castro

11

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31 May 2020

William Charles Earnshaw

12

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31 May 2020

Marcos Malumbres

13

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31 May 2020

author name string

Gonzalo Fernández-Miranda

2

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31 May 2020

David Partida

4

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31 May 2020

Kumiko Samejima

5

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31 May 2020

Hiromi Ogawa

6

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31 May 2020

Marta Cañamero

7

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31 May 2020

Ángel Martínez-Ramírez

9

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31 May 2020

language of work or name

English

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publication date

3 August 2015

1 reference

Molecular and Cellular Biology

12 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26240282%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

35

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31 May 2020

issue

20

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31 May 2020

page(s)

3566-3578

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describes a project that uses

31 May 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4573715/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Increased Aurora B activity causes continuous disruption of kinetochore-microtubule attachments and spindle instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573715

Induction of p21CIP1 protein and cell cycle arrest after inhibition of Aurora B kinase is attributed to aneuploidy and reactive oxygen species.

2 October 2017

1 reference

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2 October 2017

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Aneuploidy in health, disease, and aging

2 October 2017

1 reference

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Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1).

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573715

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.

2 October 2017

1 reference

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The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

2 October 2017

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Aurora B kinase phosphorylates and instigates degradation of p53

2 October 2017

1 reference

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A stochastic model of kinetochore-microtubule attachment accurately describes fission yeast chromosome segregation.

2 October 2017

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Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

2 October 2017

1 reference

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2 October 2017

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Use of DT40 conditional-knockout cell lines to study chromosomal passenger protein function

2 October 2017

1 reference

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Sensing centromere tension: Aurora B and the regulation of kinetochore function

2 October 2017

1 reference

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Shared and separate functions of polo-like kinases and aurora kinases in cancer

2 October 2017

1 reference

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Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression

2 October 2017

1 reference

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Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome

2 October 2017

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Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

2 October 2017

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Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia

2 October 2017

1 reference

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Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins

2 October 2017

1 reference

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Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

2 October 2017

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Deregulated Aurora-B induced tetraploidy promotes tumorigenesis

2 October 2017

1 reference

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A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes

2 October 2017

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Bub1 maintains centromeric cohesion by activation of the spindle checkpoint

2 October 2017

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A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy

2 October 2017

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

2 October 2017

1 reference

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Overexpression of aurora B kinase (AURKB) in primary non-small cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instability

2 October 2017

1 reference

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Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation

2 October 2017

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High expression of Aurora-B/Aurora and Ipll-like midbody-associated protein (AIM-1) in astrocytomas

2 October 2017

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The cellular geography of aurora kinases

2 October 2017

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2 October 2017

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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

2 October 2017

1 reference

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The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

2 October 2017

1 reference

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Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation

2 October 2017

1 reference

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Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells

2 October 2017

1 reference

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

2 October 2017

1 reference

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A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

2 October 2017

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Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast.

2 October 2017

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Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573715

Aurora kinase B expression in breast carcinoma: cell kinetic and genetic aspects.

11 July 2018

1 reference

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Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573715

Genomic stability and tumour suppression by the APC/C cofactor Cdh1.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573715

Aurora B kinase expression in ependymal neoplasms.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573715

A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573715

Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573715

Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573715

Aurora B expression in normal testis and seminomas.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573715

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573715

Frequent overexpression of aurora B kinase, a novel drug target, in non-small cell lung carcinoma patients

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26240282

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26240282

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.01286-14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26240282%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26240282%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference