Making many from few: IL-12p40 as a model for the combinatorial assembly of heterodimeric cytokines (Q36068746)

12 August 2017

1 reference

title

Making many from few: IL-12p40 as a model for the combinatorial assembly of heterodimeric cytokines (English)

1 reference

12 August 2017

Kaveh Abdi

1

1 reference

PMCID

4573263

12 August 2017

Nevil J Singh

series ordinal

2

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12 August 2017

1 August 2015

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12 August 2017

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12 August 2017

76

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12 August 2017

1

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12 August 2017

53-57

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Clusterin transcript variants expression in thyroid tumor: a potential marker of malignancy?

12 August 2017

1 reference

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Interleukin 12 (IL-12) family cytokines: Role in immune pathogenesis and treatment of CNS autoimmune disease

2 October 2017

1 reference

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Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

2 October 2017

1 reference

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Translation. An RNA biosensor for imaging the first round of translation from single cells to living animals.

2 October 2017

1 reference

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Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients

2 October 2017

1 reference

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Tissue-resident memory T cells.

2 October 2017

1 reference

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Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival

2 October 2017

1 reference

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Knockdown of clusterin expression increases the in vitro sensitivity of human prostate cancer cells to paclitaxel

2 October 2017

1 reference

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2 October 2017

1 reference

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Severe Acinetobacter baumannii sepsis is associated with elevation of pentraxin 3.

2 October 2017

1 reference

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Tailored immunity at mucosae

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1 reference

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IL-12 is required for mTOR regulation of memory CTLs during viral infection

2 October 2017

1 reference

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Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly

2 October 2017

1 reference

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Contextual functions of antigen-presenting cells in the gastrointestinal tract

2 October 2017

1 reference

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Clusterin: a key player in cancer chemoresistance and its inhibition

2 October 2017

1 reference

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IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo

2 October 2017

1 reference

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2 October 2017

1 reference

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Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell-mediated glioma rejection

2 October 2017

1 reference

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The integration of T cell migration, differentiation and function

2 October 2017

1 reference

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Custirsen (OGX-011): clusterin inhibitor in metastatic prostate cancer

2 October 2017

1 reference

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IL-12 family cytokines: immunological playmakers

2 October 2017

1 reference

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Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?

2 October 2017

1 reference

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The regulation and activity of interleukin-12.

2 October 2017

1 reference

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Two signal models in innate immunity

2 October 2017

1 reference

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Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue

2 October 2017

1 reference

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Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury.

2 October 2017

1 reference

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Development of the IL-12/23 antagonist ustekinumab in psoriasis: past, present, and future perspectives

2 October 2017

1 reference

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Antigen-activated T cells induce IL-12p75 production from dendritic cells in an IFN-γ-independent manner

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

IL-12 p40 homodimer, the so-called biologically inactive molecule, induces nitric oxide synthase in microglia via IL-12R beta 1.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

The long pentraxin 3 and its role in autoimmunity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency

2 October 2017

1 reference

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Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation

2 October 2017

1 reference

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IL-12p40: an inherently agonistic cytokine

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

IL-12: the role of p40 versus p75

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Induction of nitric-oxide synthase and activation of NF-kappaB by interleukin-12 p40 in microglial cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Cloning and expression of murine IL-12

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

AIM inhibits apoptosis of T cells and NKT cells in Corynebacterium-induced granuloma formation in mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

27 July 2018

1 reference

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Tissue-based class control: the other side of tolerance.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

A profibrotic function of IL-12p40 in experimental pulmonary fibrosis

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

A protective and agonistic function of IL-12p40 in mycobacterial infection.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573263

In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection

23 September 2018

1 reference

12 December 2020

IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity

1 reference

12 December 2020

Activation rules: the two-signal theories of immune activation

1 reference

12 December 2020

T-cell control of IL-12p75 production

1 reference

12 December 2020

IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes

1 reference

12 December 2020

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

1 reference

12 December 2020

A novel function of IL-12p40 as a chemotactic molecule for macrophages

1 reference

12 December 2020

10.1016/J.CYTO.2015.07.026

Identifiers

DOI

1 reference

12 August 2017

1 reference

12 August 2017

1 reference

PMCID

4573263