Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling (Q36053060)

11 August 2017

Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling (English)

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11 August 2017

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Y C Liao

1

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11 August 2017

J W Ruan

2

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11 August 2017

I Lua

3

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11 August 2017

M H Li

4

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11 August 2017

W L Chen

5

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11 August 2017

J R Y Wang

6

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11 August 2017

R H Kao

7

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11 August 2017

J H Chen

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11 August 2017

language of work or name

English

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publication date

17 October 2011

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11 August 2017

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11 August 2017

31

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25

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11 August 2017

3086-3097

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https://scigraph.springernature.com/pub.10.1038/onc.2011.476

11 August 2017

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cites work

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Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.

2 October 2017

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Pituitary senescence: the evolving role of Pttg

2 October 2017

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A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis

2 October 2017

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Transcriptional targets for pituitary tumor-transforming gene-1.

2 October 2017

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p21(Cip1) restrains pituitary tumor growth

2 October 2017

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Activated androgen receptor downregulates E-cadherin gene expression and promotes tumor metastasis

2 October 2017

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Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma

2 October 2017

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Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis?

2 October 2017

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GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA.

2 October 2017

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Pituitary tumor-transforming gene: physiology and implications for tumorigenesis

2 October 2017

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Cancer metastasis: building a framework

2 October 2017

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Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity.

2 October 2017

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Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells

2 October 2017

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Targeting transcription factors for cancer gene therapy.

2 October 2017

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Rho GTPases: biochemistry and biology

2 October 2017

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Securin is overexpressed in breast cancer

2 October 2017

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Roles and regulation of stat family transcription factors in human breast cancer

2 October 2017

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Rho-family GTPases: it's not only Rac and Rho (and I like it).

2 October 2017

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The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

2 October 2017

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2 October 2017

RHO-GTPases and cancer

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A molecular signature of metastasis in primary solid tumors

2 October 2017

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Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis

2 October 2017

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Dissemination and growth of cancer cells in metastatic sites

2 October 2017

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Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

2 October 2017

1 reference

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Cell motility: can Rho GTPases and microtubules point the way?

2 October 2017

1 reference

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Rho GTPases and cell migration

2 October 2017

1 reference

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Paxillin: a focal adhesion-associated adaptor protein

2 October 2017

1 reference

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Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381367

Rho GTPases: signaling, migration, and invasion

2 October 2017

1 reference

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A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product

2 October 2017

1 reference

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Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381367

Structure, expression, and function of human pituitary tumor-transforming gene (PTTG)

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381367

Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381367

hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG

2 October 2017

1 reference

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Rho proteins induce metastatic properties in vivo

2 October 2017

1 reference

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Rho GTPases and the actin cytoskeleton

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381367

Isolation and characterization of a pituitary tumor-transforming gene (PTTG)

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381367

Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381367

Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381367

Pituitary tumor transforming gene (PTTG) transforming and transactivation activity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381367

GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381367

The dual mechanism of separase regulation by securin

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381367

Identification of c-myc as a down-stream target for pituitary tumor-transforming gene

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381367

Expression of pituitary-tumour transforming gene in colorectal tumours

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2011.476

PTTG mRNA expression in primary breast cancer: a prognostic marker for lymph node invasion and tumor recurrence

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2011.476

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.476

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

22002306

1 reference