Suppression of Ras/Mapk pathway signaling inhibits Myc-induced lymphomagenesis (Q36028499)

11 August 2017

Suppression of Ras/Mapk pathway signaling inhibits Myc-induced lymphomagenesis (English)

1 reference

11 August 2017

M W Gramling

1

1 reference

PMCID

3374085

11 August 2017

C M Eischen

series ordinal

2

1 reference

11 August 2017

3 February 2012

1 reference

Cell Death & Differentiation

11 August 2017

1 reference

11 August 2017

19

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11 August 2017

7

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11 August 2017

1220-1227

1 reference

https://scigraph.springernature.com/pub.10.1038/cdd.2012.1

11 August 2017

0 references

cites work

The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma

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KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels

2 October 2017

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CREBBP mutations in relapsed acute lymphoblastic leukaemia

2 October 2017

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High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade.

2 October 2017

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Pharmacologic inactivation of kinase suppressor of Ras1 sensitizes epidermal growth factor receptor and oncogenic Ras-dependent tumors to ionizing radiation treatment

2 October 2017

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Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model

2 October 2017

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Modelling Myc inhibition as a cancer therapy

2 October 2017

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Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study.

2 October 2017

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Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas

2 October 2017

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Oncogene addiction versus oncogene amnesia: perhaps more than just a bad habit?

2 October 2017

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KSR and CNK: two scaffolds regulating RAS-mediated RAF activation

2 October 2017

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Integrating signals from RTKs to ERK/MAPK.

2 October 2017

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The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence

2 October 2017

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Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity

2 October 2017

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Bim is a suppressor of Myc-induced mouse B cell leukemia

2 October 2017

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Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer

2 October 2017

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Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis

2 October 2017

1 reference

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Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.

2 October 2017

1 reference

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Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

Ras enhances Myc protein stability.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

Overexpression of the MDM2 oncogene in leukemia and lymphoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

Lymphomagenesis in E mu-myc transgenic mice can involve ras mutations.

27 July 2018

1 reference

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Acceleration of B-lymphoid tumorigenesis in E mu-myc transgenic mice by v-H-ras and v-raf but not v-abl

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

Integrative genomic profiling reveals conserved genetic mechanisms for tumorigenesis in common entities of non-Hodgkin's lymphoma.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

Aberrations of the p53 pathway components p53, MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374085

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

23 September 2018

2 references

Crossref

https://api.crossref.org/works/10.1038%2FCDD.2012.1

21 January 2018

12 December 2020

Aberrations of the p53 pathway components p53, MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FCDD.2012.1

RAS mutations are rare events in Philadelphia chromosome-negative/bcr gene rearrangement-negative chronic myelogenous leukemia, but are prevalent in chronic myelomonocytic leukemia

21 January 2018

1 reference

PubMed

12 December 2020

Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation

1 reference

PubMed

12 December 2020

Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells

1 reference

PubMed

12 December 2020

Identifiers

DOI

10.1038/CDD.2012.1

1 reference

PMCID

3374085

Dimensions Publication ID

11 August 2017

0 references

1 reference

11 August 2017

1 reference

PMCID

3374085