Animal Models of Gastrointestinal and Liver Diseases. The difficulty of animal modeling of pancreatic cancer for preclinical evaluation of therapeutics (Q36017810)

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Language	Label	Description	Also known as
English	Animal Models of Gastrointestinal and Liver Diseases. The difficulty of animal modeling of pancreatic cancer for preclinical evaluation of therapeutics	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

1 reference

Europe PubMed Central

Animal Models of Gastrointestinal and Liver Diseases. The difficulty of animal modeling of pancreatic cancer for preclinical evaluation of therapeutics (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

pancreatic cancer

1 reference

based on heuristic

inferred from title

author name string

Craig D Logsdon

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Thiruvengadam Arumugam

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Vijaya Ramachandran

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

publication date

9 July 2015

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

American Journal of Physiology - Gastrointestinal and Liver Physiology

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

309

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

5

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

G283-91

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Whole genomes redefine the mutational landscape of pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

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Concise review: humanized models of tumor immunology in the 21st century: convergence of cancer research and tissue engineering

1 reference

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Hypermutation in human cancer genomes: footprints and mechanisms

1 reference

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The conflicting roles of tumor stroma in pancreatic cancer and their contribution to the failure of clinical trials: a systematic review and critical appraisal

1 reference

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Pancreatic cancer and its stroma: a conspiracy theory

1 reference

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2 October 2017

Human cancer growth and therapy in immunodeficient mouse models

1 reference

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Heterogeneity of pancreatic cancer metastases in a single patient revealed by quantitative proteomics

1 reference

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Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

1 reference

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Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma

1 reference

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Stars and stripes in pancreatic cancer: role of stellate cells and stroma in cancer progression

1 reference

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1 reference

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1 reference

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Novel pancreatic cancer cell lines derived from genetically engineered mouse models of spontaneous pancreatic adenocarcinoma: applications in diagnosis and therapy

1 reference

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2 October 2017

Pathogenesis of pancreatic cancer: lessons from animal models

1 reference

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Cross-species analysis of mouse and human cancer genomes.

1 reference

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Humanized mice as a model to study human hematopoietic stem cell transplantation.

1 reference

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A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice

1 reference

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Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer

1 reference

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2 October 2017

Relevance of animal models of pancreatic cancer and pancreatitis to human disease

1 reference

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2 October 2017

Genetically engineered mouse models of pancreatic adenocarcinoma

1 reference

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2 October 2017

Evolution and dynamics of pancreatic cancer progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Cancer statistics, 2013

1 reference

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2 October 2017

Oncogenic K-Ras requires activation for enhanced activity

1 reference

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2 October 2017

Challenges and advances in mouse modeling for human pancreatic tumorigenesis and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Humanized mice for immune system investigation: progress, promise and challenges

1 reference

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2 October 2017

EGF receptor is required for KRAS-induced pancreatic tumorigenesis

1 reference

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Immuno-oncology: understanding the function and dysfunction of the immune system in cancer

1 reference

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The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

1 reference

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2 October 2017

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Genomic sequencing of key genes in mouse pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

StellaTUM: current consensus and discussion on pancreatic stellate cell research

1 reference

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2 October 2017

PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Molecular profiling of direct xenograft tumors established from human pancreatic adenocarcinoma after neoadjuvant therapy

1 reference

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2 October 2017

A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

1 reference

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2 October 2017

Hallmarks of Cancer: The Next Generation

1 reference

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2 October 2017

Mouse models of advanced spontaneous metastasis for experimental therapeutics

1 reference

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2 October 2017

S100P: a novel therapeutic target for cancer

1 reference

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2 October 2017

Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer

1 reference

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Ras activity levels control the development of pancreatic diseases.

1 reference

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Lineage-specific biology revealed by a finished genome assembly of the mouse

1 reference

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2 October 2017

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

1 reference

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A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Epigenetic changes in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Update on pancreatic intraepithelial neoplasia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Musashi1 modulates mammary progenitor cell expansion through proliferin-mediated activation of the Wnt and Notch pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Cancer-associated stromal fibroblasts promote pancreatic tumor progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Gemcitabine has significant immunomodulatory activity in murine tumor models independent of its cytotoxic effects

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2 October 2017

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1 reference

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2 October 2017

S100P is an early developmental marker of pancreatic carcinogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

S100P promotes pancreatic cancer growth, survival, and invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Precursors to invasive pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Of mice and not men: differences between mouse and human immunology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Breeding of a non-obese, diabetic strain of mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

A severe combined immunodeficiency mutation in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

Mutator phenotype may be required for multistage carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

2 October 2017

A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

11 July 2018

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

11 July 2018

Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

11 July 2018

Pancreatic acinar cells in culture: expression of acinar and ductal antigens in a growth-related manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

11 July 2018

Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

23 September 2018

Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

23 September 2018

The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

23 September 2018

Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4556944

23 September 2018

Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/26159697

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/26159697

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

‘Nude’, a new hairless gene with pleiotropic effects in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/26159697

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinicopathological Correlates of Pancreatic Intraepithelial Neoplasia: A Comparative Analysis of 82 Cases With and 152 Cases Without Pancreatic Ductal Adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26159697

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species- and cell type-specific requirements for cellular transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26159697

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inability of intravenously injected monocellular suspensions of human bone marrow to establish in the nude mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/26159697

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPGI.00169.2015

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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