Procainamide is a specific inhibitor of DNA methyltransferase 1. (Q36008593)

11 August 2017

Procainamide is a specific inhibitor of DNA methyltransferase 1. (English)

1 reference

Srinivasan Yegnasubramanian

11 August 2017

1 reference

ChEBI release 2020-05-28

ChEBI ID

8428

author

series ordinal

2

object named as

Srinivasan Yegnasubramanian

1 reference

11 August 2017

Byron H Lee

1

1 reference

11 August 2017

Xiaohui Lin

series ordinal

3

1 reference

11 August 2017

William G Nelson

series ordinal

4

1 reference

11 August 2017

language of work or name

English

0 references

publication date

17 October 2005

1 reference

Journal of Biological Chemistry

11 August 2017

1 reference

11 August 2017

280

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11 August 2017

40749-40756

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11 August 2017

49

1 reference

DNA cytosine C5 methyltransferase Dnmt1: catalysis-dependent release of allosteric inhibition

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes

2 October 2017

1 reference

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Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Selective RNA Binding by a Single CCCH Zinc-Binding Domain from Nup475 (Tristetraprolin)

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Induction of Tumors in Mice by Genomic Hypomethylation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

2 October 2017

1 reference

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Worms gang up on bacteria

2 October 2017

1 reference

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DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

GSTP1 CpG island hypermethylation is responsible for the absence of GSTP1 expression in human prostate cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

CpG methylation is maintained in human cancer cells lacking DNMT1.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveal allosteric activation by methylated dna.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Role of DNA 5-methylcytosine transferase in cell transformation by fos

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Murine DNA cytosine-C5 methyltransferase: pre-steady- and steady-state kinetic analysis with regulatory DNA sequences

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Number of CpG islands and genes in human and mouse

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-captur

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Suppression of intestinal neoplasia by DNA hypomethylation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Cellular differentiation, cytidine analogs and DNA methylation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Furanose-pyranose isomerization of reduced pyrimidine and cyclic urea ribosides

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Molecular characterization of human minichromosomes with centromere from chromosome 1 in human-hamster hybrid cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Procainamide inhibits DNA methyltransferase in a human T cell line

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Inhibition of DNA methylation and reactivation of silenced genes by zebularine

11 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505593200

Mutagenicity of the cytidine analog zebularine in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505593200

Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505593200

CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505593200

Recombinant Human DNA (Cytosine-5) Methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505593200

Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1989680

DNA methylation and globin gene expression in patients treated with 5-azacytidine

23 September 2018

1 reference

12 December 2020

Purification of human DNA (cytosine-5-)-methyltransferase

1 reference

12 December 2020

Two subsets of human alphoid repetitive DNA show distinct preferential localization in the pericentric regions of chromosomes 13, 18, and 21

1 reference

12 December 2020

Effects of lupus-inducing drugs on the B to Z transition of synthetic DNA

1 reference

12 December 2020

Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity

1 reference

12 December 2020

Lupus-inducing drugs alter the structure of supercoiled circular dna domains

1 reference

12 December 2020

Testing of metoclopramide and procainamide for their ability to induce genotoxic effects in cultured mammalian cells

1 reference

12 December 2020

Evaluation of DNA-damaging, clastogenic, and promoting activities of metoclopramide and procainamide in rats

1 reference

12 December 2020

CG island methylation changes near the GSTP1 gene in prostatic intraepithelial neoplasia

1 reference

12 December 2020

Processive methylation of hemimethylated CpG sites by mouse Dnmt1 DNA methyltransferase

1 reference

12 December 2020

Molecular analysis of 5-azacytidine-induced variants in mammalian cells

1 reference

12 December 2020

5-Azacytidine, a new, highly effective cancerostatic

1 reference

12 December 2020

5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia

1 reference

12 December 2020

5-Azacytidine increases fetal hemoglobin production in a patient with sickle cell disease

1 reference

12 December 2020

The fundamental role of epigenetic events in cancer

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M505593200

1 reference

11 August 2017

1 reference

11 August 2017

1 reference