Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products (Q36007617)

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English	Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products	scientific article

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scholarly article

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Europe PubMed Central

11 August 2017

Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products (English)

1 reference

Europe PubMed Central

11 August 2017

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ChEBI release 2020-05-28

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author name string

Kwang Seok Ahn

1

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Europe PubMed Central

11 August 2017

Gautam Sethi

2

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Europe PubMed Central

11 August 2017

Ta-Hsiang Chao

3

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Europe PubMed Central

11 August 2017

Saskia T C Neuteboom

4

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Europe PubMed Central

11 August 2017

Madan M Chaturvedi

5

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Europe PubMed Central

11 August 2017

Michael A Palladino

6

1 reference

Europe PubMed Central

11 August 2017

Anas Younes

7

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Europe PubMed Central

11 August 2017

Bharat B Aggarwal

8

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Europe PubMed Central

11 August 2017

language of work or name

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publication date

3 July 2007

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Europe PubMed Central

11 August 2017

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Europe PubMed Central

11 August 2017

110

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11 August 2017

7

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11 August 2017

2286-2295

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Europe PubMed Central

11 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1988928/fullTextXML

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NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells

1 reference

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Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products

1 reference

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Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma

1 reference

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2 October 2017

Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding

1 reference

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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

1 reference

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Nuclear factor-kappaB activation: a question of life or death

1 reference

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1 reference

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Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor

1 reference

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Nuclear factor-kappaB: the enemy within

1 reference

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Nuclear factor-kappaB: its role in health and disease

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1 reference

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1 reference

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Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

1 reference

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1 reference

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1 reference

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Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

1 reference

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

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IkappaB kinase: beginning, not the end

1 reference

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Cyclin D1 is a nuclear protein required for cell cycle progression in G1

1 reference

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1 reference

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Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B

1 reference

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Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo.

1 reference

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1 reference

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1 reference

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The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia.

1 reference

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23 September 2018

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1 reference

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1 reference

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Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2007-04-084996

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

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