Targeted toxins for glioblastoma multiforme: pre-clinical studies and clinical implementation. (Q35999648)

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6 February 2020

review article

1 reference

title

Targeted toxins for glioblastoma multiforme: pre-clinical studies and clinical implementation (English)

1 reference

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6 February 2020

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12

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6 February 2020

Maria G. Castro

14

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6 February 2020

author name string

Marianela Candolfi

1

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6 February 2020

Kurt M Kroeger

2

1 reference

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6 February 2020

Weidong Xiong

3

1 reference

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6 February 2020

Chunyan Liu

4

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6 February 2020

Mariana Puntel

5

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6 February 2020

Kader Yagiz

6

1 reference

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6 February 2020

Akm Ghulam Muhammad

7

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6 February 2020

Yohei Mineharu

8

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6 February 2020

David Foulad

9

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6 February 2020

Mia Wibowo

10

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6 February 2020

Hikmat Assi

11

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6 February 2020

Pedro R Lowenstein

13

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6 February 2020

language of work or name

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1 October 2011

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Anti-Cancer Agents in Medicinal Chemistry

6 February 2020

published in

1 reference

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6 February 2020

volume

11

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6 February 2020

issue

8

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6 February 2020

page(s)

729-738

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Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics.

6 February 2020

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Expression of interleukin-13 receptor alpha2 in glioblastoma multiforme: implications for targeted therapies

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Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study

2 October 2017

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2 October 2017

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2 October 2017

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Diphtheria Toxin−Epidermal Growth Factor Fusion Protein and Pseudomonas Exotoxin−Interleukin 13 Fusion Protein Exert Synergistic Toxicity against Human Glioblastoma Multiforme Cells

2 October 2017

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2 October 2017

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2 October 2017

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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27 July 2018

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27 July 2018

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23 September 2018

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Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin.

23 September 2018

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Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning.

23 September 2018

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Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients.

23 September 2018

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Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13-PE38QQR for recurrent malignant glioma

23 September 2018

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Analysis of interleukin-13 receptor alpha2 expression in human pediatric brain tumors.

23 September 2018

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A bispecific immunotoxin (DTAT13) targeting human IL-13 receptor (IL-13R) and urokinase-type plasminogen activator receptor (uPAR) in a mouse xenograft model.

23 September 2018

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Combination fusion protein therapy of refractory brain tumors: demonstration of efficacy in cell culture.

23 September 2018

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Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malig

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

Growth factor receptor expression varies among high-grade gliomas and normal brain: epidermal growth factor receptor has excellent properties for interstitial fusion protein therapy.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

Regulated, adenovirus-mediated delivery of tyrosine hydroxylase suppresses growth of estrogen-induced pituitary prolactinomas

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

Interleukin-13 receptor as a unique target for anti-glioblastoma therapy

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

Expression of a restrictive receptor for interleukin 13 is associated with glial transformation.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

In vivo expression of the interleukin 4 receptor alpha by astrocytes in epilepsy cerebral cortex.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

Expression and significance of urokinase type plasminogen activator gene in human brain gliomas.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

Retargeting interleukin 13 for radioimmunodetection and radioimmunotherapy of human high-grade gliomas

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

Human glioma cells overexpress receptors for interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and pseudomonas exotoxin.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

Novel anti-brain tumor cytotoxins specific for cancer cells.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

An immunotoxin with increased activity and homogeneity produced by reducing the number of lysine residues in recombinant Pseudomonas exotoxin.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

Transferrin receptor on endothelium of brain capillaries

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364590

Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin A (PE38QQR)

23 September 2018

1 reference

12 December 2020

Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein

1 reference

12 December 2020

A novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4

1 reference

12 December 2020

The role of the diphtheria toxin receptor in cytosol translocation

1 reference

12 December 2020

Efficacy of antiangiogenic targeted toxins against glioblastoma multiforme

1 reference

12 December 2020

Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric toxin protein

1 reference

12 December 2020

Calorimetric studies of the binding of ferric ions to human serum transferrin

1 reference

12 December 2020

The IL-13 receptor structure differs on various cell types and may share more than one component with IL-4 receptor

1 reference

12 December 2020

10.2174/187152011797378689

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21707497%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21707497%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21707497%20AND%20SRC:MED&resulttype=core&format=json