Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology (Q35959633)

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English	Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology	scientific article

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scholarly article

1 reference

Europe PubMed Central

11 August 2017

Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology (English)

1 reference

Europe PubMed Central

11 August 2017

Alzheimer's disease

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0 references

1 reference

based on heuristic

inferred from title

author name string

Maria Teresa Ferretti

1

1 reference

Europe PubMed Central

11 August 2017

Simon Allard

2

1 reference

Europe PubMed Central

11 August 2017

Vanessa Partridge

3

1 reference

Europe PubMed Central

11 August 2017

Adriana Ducatenzeiler

4

1 reference

Europe PubMed Central

11 August 2017

A Claudio Cuello

5

1 reference

Europe PubMed Central

11 August 2017

publication date

2 April 2012

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Europe PubMed Central

11 August 2017

Journal of Neuroinflammation

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Europe PubMed Central

11 August 2017

9

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Europe PubMed Central

11 August 2017

62

1 reference

Europe PubMed Central

11 August 2017

https://scigraph.springernature.com/pub.10.1186/1742-2094-9-62

0 references

Extended results of the Alzheimer's disease anti-inflammatory prevention trial

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2 October 2017

Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration

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2 October 2017

Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial

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2 October 2017

Does a pro-inflammatory process precede Alzheimer's disease and mild cognitive impairment?

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2 October 2017

CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice

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2 October 2017

Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature

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2 October 2017

Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation

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2 October 2017

Probing the biology of Alzheimer's disease in mice

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2 October 2017

Systemic inflammatory cells fight off neurodegenerative disease

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2 October 2017

Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

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Troubleshooting methods for APP processing in vitro

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Increased matrix metalloproteinase 9 activity in mild cognitive impairment

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NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease.

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2 October 2017

Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease

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2 October 2017

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

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2 October 2017

Microglial activation and amyloid deposition in mild cognitive impairment: a PET study

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2 October 2017

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

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2 October 2017

Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib

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2 October 2017

Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention

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2 October 2017

Minocycline and cytoprotection: shedding new light on a shadowy controversy.

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2 October 2017

Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models

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2 October 2017

Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry

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2 October 2017

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

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2 October 2017

Inflammatory changes parallel the early stages of Alzheimer disease

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2 October 2017

Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD

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2 October 2017

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

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2 October 2017

Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease

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2 October 2017

Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

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NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies

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Interleukin-1 mediates Alzheimer and Lewy body pathologies.

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2 October 2017

A specific amyloid-beta protein assembly in the brain impairs memory

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2 October 2017

Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice

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2 October 2017

The microglial "activation" continuum: from innate to adaptive responses

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2 October 2017

Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice

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2 October 2017

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

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2 October 2017

Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics

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2 October 2017

Signaling via NF-kappaB in the nervous system

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Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease

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2 October 2017

Amyloid accumulation and pathogensis of Alzheimer's disease: significance of monomeric, oligomeric and fibrillar Abeta.

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Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease

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BACE1: the beta-secretase enzyme in Alzheimer's disease

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Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

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Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

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Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

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Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide

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The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins

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Selective up-regulation of I kappaB-alpha in ischemic penumbra following focal cerebral ischemia

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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2 October 2017

Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease

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Risk of Alzheimer's disease and duration of NSAID use.

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NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway

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Identification and characterization of a kappa B/Rel binding site in the regulatory region of the amyloid precursor protein gene.

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Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids

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2 October 2017

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

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2 October 2017

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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2 October 2017

Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice

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Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression.

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Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

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Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation

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11 July 2018

Enhancement of immunoreactivity for NF-kappa B in the hippocampal formation and cerebral cortex of Alzheimer's disease.

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11 July 2018

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24 September 2018

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24 September 2018

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24 September 2018

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24 September 2018

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24 September 2018

Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid.

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24 September 2018

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24 September 2018

Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.

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24 September 2018

Beta-site APP cleaving enzyme 1 (BACE1) is increased in remaining neurons in Alzheimer's disease brains

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24 September 2018

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

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24 September 2018

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24 September 2018

A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment

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24 September 2018

Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline

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24 September 2018

Increased beta-secretase activity and expression in rats following transient cerebral ischemia

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24 September 2018

Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection

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24 September 2018

The impact of Aβ-plaques on cortical cholinergic and non-cholinergic presynaptic boutons in alzheimer's disease-like transgenic mice

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24 September 2018

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

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24 September 2018

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial

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24 September 2018

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352127

24 September 2018

Altered processing of amyloid precursor protein in the human neuroblastoma SH-SY5Y by chronic hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352127

24 September 2018

Oxidative stress increases expression and activity of BACE in NT2 neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352127

24 September 2018

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352127

24 September 2018

Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352127

24 September 2018

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352127

24 September 2018

Enhanced expression of I-kappaB with neurofibrillary pathology in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352127

24 September 2018

Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352127

24 September 2018

NF-kB immunoreactivity is observed in association with beta A4 diffuse plaques in patients with Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352127

24 September 2018

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352127

24 September 2018

Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-62

21 January 2018

Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease?: The Rotterdam Study

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-62

21 January 2018

Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22472085

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22472085

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1742-2094-9-62

1 reference

Europe PubMed Central

11 August 2017

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

ResearchGate publication ID

0 references

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