Opioid analgesics as noncompetitive N-methyl-D-aspartate (NMDA) antagonists (Q43070644)

13 November 2017

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title

Opioid analgesics as noncompetitive N-methyl-D-aspartate (NMDA) antagonists (English)

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13 November 2017

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Lona Louring Christrup

4

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13 November 2017

Ebert B

1

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13 November 2017

Thorkildsen C

2

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13 November 2017

Andersen S

3

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13 November 2017

Hjeds H

5

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13 November 2017

language of work or name

English

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publication date

1 September 1998

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13 November 2017

Biochemical Pharmacology

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13 November 2017

56

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13 November 2017

5

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13 November 2017

553-559

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Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene

13 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Relationship between analgesia and extracellular morphine in brain and spinal cord in awake rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Plasma and cerebrospinal fluid concentrations of morphine and morphine glucuronides after oral morphine. The influence of renal failure.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

A comparison of the effectiveness of intravenous morphine at attenuating the nociceptive responses of medullary dorsal horn and thalamic neurones.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

The ionic mechanisms underlying opioid actions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Twelfth Gaddum memorial lecture. Drug receptors and the inhibition of nerve cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Morphine responsiveness of chronic pain: double-blind randomised crossover study with patient-controlled analgesia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

The utility of excitatory amino acid (EAA) antagonists as analgesic agents. II. Assessment of the antinociceptive activity of combinations of competitive and non-competitive NMDA antagonists with agents acting at allosteric-glycine and polyamine rec

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

The utility of excitatory amino acid (EAA) antagonists as analgesic agents. I. Comparison of the antinociceptive activity of various classes of EAA antagonists in mechanical, thermal and chemical nociceptive tests.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Dextromethorphan and neuromodulation: old drug coughs up new activities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Metabolism of ketamine stereoisomers by human liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Pharmacokinetics and analgesic effects of i.m. and oral ketamine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Ketamine acts as a non-competitive N-methyl-D-aspartate antagonist on frog spinal cord in vitro.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Ketamine: an update on the first twenty-five years of clinical experience

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Identification of a novel NMDA receptor in rat cerebellum.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Dextromethorphan for the treatment of neuropathic pain: a double-blind randomised controlled crossover trial with integral n-of-1 design

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

The N-methyl-D-aspartate receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Dextromethorphan attenuates and reverses analgesic tolerance to morphine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Wind-up and the NMDA receptor: from animal studies to humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Studies on a new spasmolytic compound 1,1-diphenyl-3-dimethylaminobutene-1 (A29), related to methadone, and on the combined use of this compound and a potent analgesic, ketobemidone (A21)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Ketobemidone, methadone and pethidine are non-competitive N-methyl-D-aspartate (NMDA) antagonists in the rat cortex and spinal cord

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

The opioid receptor binding profiles of ketobemidone and morphine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

The opioid ketobemidone has a NMDA blocking effect

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Single-Dose Kinetics and Bioavailability of Ketobemidone

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Interaction of the chiral forms of ketamine with opioid, phencyclidine, sigma and muscarinic receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Effects of antidepressant drugs on different receptors in the brain

7 January 2021

1 reference

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Tricyclic antidepressants block N-methyl-D-aspartate receptors: similarities to the action of zinc

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Intrathecal amitriptyline acts as an N-methyl-D-aspartate receptor antagonist in the presence of inflammatory hyperalgesia in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

The antinociceptive effect of ketobemidone in comparison with Ketogin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Ketobemidone plus (RS)-3-dimethylamino-1,1-diphenylbut-1-ene (A29) is more potent at NMDA receptors than ketobemidone alone: evidence for A29 as a non-competitive NMDA receptor antagonist.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

The d- and l-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

The biotransformation of methadone in man: synthesis and identification of a major metabolite.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Dextropropoxyphene acts as a noncompetitive N-methyl-D-aspartate antagonist.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Structure and activity of hydrogenated derivatives of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-methyl-D-aspartate antagonists

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

Opioids and non-opioid enantiomers selectively attenuate N-methyl-D-aspartate neurotoxicity on cortical neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900088-4

10.1016/S0006-2952(98)00088-4

7 January 2021

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DOI

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13 November 2017

1 reference