PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail (Q35919920)

11 August 2017

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail (English)

1 reference

11 August 2017

1 reference

Smoothened Dmel_CG11561

1 reference

Patched Dmel_CG2411

1 reference

G protein-coupled receptor kinase 2 Dmel_CG17998

1 reference

Costa Dmel_CG1708

1 reference

1 reference

6

B Mark Evers

1 reference

11 August 2017

Kai Jiang

1

1 reference

11 August 2017

Yajuan Liu

2

1 reference

11 August 2017

Junkai Fan

3

1 reference

11 August 2017

Jie Zhang

4

1 reference

11 August 2017

Xiang-An Li

5

1 reference

11 August 2017

Haining Zhu

7

1 reference

11 August 2017

Jianhang Jia

8

1 reference

11 August 2017

language of work or name

English

0 references

publication date

10 February 2016

1 reference

11 August 2017

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11 August 2017

14

1 reference

11 August 2017

e1002375

1 reference

11 August 2017

2

1 reference

Creative Commons Attribution 4.0 International

11 August 2017

start time

10 February 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4749301/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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The role of ciliary trafficking in Hedgehog receptor signaling

11 July 2018

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Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila

11 July 2018

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Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling

11 July 2018

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Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

11 July 2018

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CARMIL leading edge localization depends on a non-canonical PH domain and dimerization

11 July 2018

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The mechanisms of Hedgehog signalling and its roles in development and disease

11 July 2018

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Structure of the human smoothened receptor bound to an antitumour agent

11 July 2018

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Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner

11 July 2018

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Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila

11 July 2018

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USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization

11 July 2018

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Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened

11 July 2018

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Mechanisms and functions of Hedgehog signalling across the metazoa

11 July 2018

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Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.

11 July 2018

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Ihog and Boi are essential for Hedgehog signaling in Drosophila.

11 July 2018

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Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus

11 July 2018

1 reference

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G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

11 July 2018

1 reference

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Role of lipid metabolism in smoothened derepression in hedgehog signaling

11 July 2018

1 reference

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Mechanism and evolution of cytosolic Hedgehog signal transduction

11 July 2018

1 reference

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Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling

11 July 2018

1 reference

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Genetic and biochemical definition of the Hedgehog receptor

11 July 2018

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Patched regulates Smoothened trafficking using lipoprotein-derived lipids.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

11 July 2018

1 reference

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Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

11 July 2018

1 reference

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Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

11 July 2018

1 reference

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PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation

11 July 2018

1 reference

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Hedgehog signaling in development and cancer.

11 July 2018

1 reference

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The Skap-hom Dimerization and PH Domains Comprise a 3′-Phosphoinositide-Gated Molecular Switch

11 July 2018

1 reference

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Hedgehog regulates smoothened activity by inducing a conformational switch

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Patched1 regulates hedgehog signaling at the primary cilium

11 July 2018

1 reference

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Phosphoinositides in cell regulation and membrane dynamics

11 July 2018

1 reference

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Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

11 July 2018

1 reference

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Phosphatidic acid- and phosphatidylserine-binding proteins

11 July 2018

1 reference

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Decoding the Hedgehog signal in animal development.

11 July 2018

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Communicating with Hedgehogs

11 July 2018

1 reference

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Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

11 July 2018

1 reference

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Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

The Hedgehog response network: sensors, switches, and routers

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Patched acts catalytically to suppress the activity of Smoothened

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

The sterol-sensing domain: multiple families, a unique role?

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Hedgehog signaling in animal development: paradigms and principles

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

The Drosophila G-protein-coupled receptor kinase homologue Gprk2 is required for egg morphogenesis.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Teratogen-mediated inhibition of target tissue response to Shh signaling.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

Direct and long-range action of a DPP morphogen gradient.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749301

G protein-coupled receptor kinases

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26863604

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Distribution of signaling molecules involved in vasopressin-induced Ca2+ mobilization in rat hepatocyte multiplets

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26863604

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PBIO.1002375

1 reference

11 August 2017

1 reference

11 August 2017

1 reference