Orthotopic mouse models for the preclinical and translational study of targeted therapies against metastatic human thyroid carcinoma with BRAF(V600E) or wild-type BRAF (Q35914464)

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scientific article published on 23 December 2013

Language	Label	Description	Also known as
English	Orthotopic mouse models for the preclinical and translational study of targeted therapies against metastatic human thyroid carcinoma with BRAF(V600E) or wild-type BRAF	scientific article published on 23 December 2013

Statements

scholarly article

1 reference

Europe PubMed Central

11 August 2017

Orthotopic mouse models for the preclinical and translational study of targeted therapies against metastatic human thyroid carcinoma with BRAF(V600E) or wild-type BRAF (English)

1 reference

Europe PubMed Central

11 August 2017

thyroid carcinoma

1 reference

based on heuristic

inferred from title

Zeus Andrea Antonello

1

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24362526%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

C Nucera

2

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12 June 2020

language of work or name

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publication date

23 December 2013

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Europe PubMed Central

11 August 2017

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12 June 2020

33

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Europe PubMed Central

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12 June 2020

5397-5404

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47

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12 June 2020

https://scigraph.springernature.com/pub.10.1038/onc.2013.544

0 references

Effective utilization and appropriate selection of genetically engineered mouse models for translational integration of mouse and human trials

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11 July 2018

Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAF(V600E)-induced thyroid tumors in a mouse model

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Recent progress of genome study for anaplastic thyroid cancer

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Src inhibitors in suppression of papillary thyroid carcinoma growth.

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Synergistic inhibition of thyroid cancer by suppressing MAPK/PI3K/AKT pathways

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Lessons learned and questions unanswered from use of multitargeted kinase inhibitors in medullary thyroid cancer

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Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma

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Clinical responses to vemurafenib in patients with metastatic papillary thyroid cancer harboring BRAF(V600E) mutation

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Molecular pathogenesis and mechanisms of thyroid cancer

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Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas.

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New targeted therapies and other advances in the management of anaplastic thyroid cancer

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FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma

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Targeted inhibition of Src kinase with dasatinib blocks thyroid cancer growth and metastasis.

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EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib

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Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

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Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation

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Late intervention with anti-BRAF(V600E) therapy induces tumor regression in an orthotopic mouse model of human anaplastic thyroid cancer

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Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation

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Activation of tumor cell proliferation by thyroid hormone in a mouse model of follicular thyroid carcinoma

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Improved survival with vemurafenib in melanoma with BRAF V600E mutation

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Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer

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11 July 2018

Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse

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Thyroid cancer: burden of illness and management of disease

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11 July 2018

Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer

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11 July 2018

BRAF mutation-selective inhibition of thyroid cancer cells by the novel MEK inhibitor RDEA119 and genetic-potentiated synergism with the mTOR inhibitor temsirolimus.

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Thyroid cancer in 2010: a roadmap for targeted therapies

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11 July 2018

Targeted therapy of VEGFR2 and EGFR significantly inhibits growth of anaplastic thyroid cancer in an orthotopic murine model.

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Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice

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11 July 2018

The BRAFT1799A mutation confers sensitivity of thyroid cancer cells to the BRAFV600E inhibitor PLX4032 (RG7204).

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11 July 2018

Thyroidectomy with neoadjuvant PLX4720 extends survival and decreases tumor burden in an orthotopic mouse model of anaplastic thyroid cancer

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11 July 2018

Thyroid cancer resistance to vitamin D receptor activation is associated with 24-hydroxylase levels but not the ff FokI polymorphism

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Akt inhibitors in clinical development for the treatment of cancer

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

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Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer

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RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models

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B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression

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Dasatinib: a potent SRC inhibitor in clinical development for the treatment of solid tumors

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

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Establishment and genomic characterization of mouse xenografts of human primary prostate tumors

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The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors

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Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer

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Phase I clinical trials in 56 patients with thyroid cancer: the M. D. Anderson Cancer Center experience

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A novel orthotopic mouse model of human anaplastic thyroid carcinoma

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Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1.

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Role of B-Raf(V600E) in differentiated thyroid cancer and preclinical validation of compounds against B-Raf(V600E).

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Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo

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Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification

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Sorafenib potently inhibits papillary thyroid carcinomas harboring RET/PTC1 rearrangement

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Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma

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BRAFV600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase kinase inhibition in thyroid cancer cell lines

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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

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Src continues aging: current and future clinical directions.

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FOXM1, a typical proliferation-associated transcription factor

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RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis

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Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy.

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BAY 43-9006 inhibition of oncogenic RET mutants

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Hürthle cell carcinoma

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Modeling metastasis in the mouse

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Detection of residual and recurrent thyroid cancer by radionuclide imaging

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Orthotopic models are necessary to predict therapy of transplantable tumors in mice

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Medullary thyroid carcinoma: clinical features and long-term follow-up of seventy-eight patients treated between 1969 and 1986.

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Vitamin D receptors and anti-proliferative effects of vitamin D derivatives in human pancreatic carcinoma cells in vivo and in vitro

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Prognostic factors and risk group analysis in follicular carcinoma of the thyroid

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Correlation of drug response in patients and in the clonogenic assay with solid human tumour xenografts

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The SCID mouse mutant: definition, characterization, and potential uses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524291

11 July 2018

Postnatal expression of BRAFV600E does not induce thyroid cancer in mouse models of thyroid papillary carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524291

24 September 2018

Is thyroid cancer recurrence risk increased after transplantation?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524291

24 September 2018

BRAF V600E inhibition in anaplastic thyroid cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524291

24 September 2018

Increasing incidence of thyroid cancer: controversies explored

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524291

24 September 2018

Inhibition of Src with AZD0530 reveals the Src-Focal Adhesion kinase complex as a novel therapeutic target in papillary and anaplastic thyroid cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524291

24 September 2018

The melanoma-associated antigen A3 mediates fibronectin-controlled cancer progression and metastasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524291

24 September 2018

Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524291

24 September 2018

BRAF is a therapeutic target in aggressive thyroid carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524291

24 September 2018

Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524291

24 September 2018

Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524291

24 September 2018

Follicular and Hürthle cell carcinoma: predicting outcome and directing therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524291

24 September 2018

Prognostic factors for survival and for biochemical cure in medullary thyroid carcinoma: results in 899 patients. The GETC Study Group. Groupe d'étude des tumeurs à calcitonine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524291

24 September 2018

American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.544

21 January 2018

High-throughput oncogene mutation profiling in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.544

21 January 2018

Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524291

14 November 2018

Increasing incidence of thyroid cancer in the United States, 1973-2002

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.544

31 March 2020

Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.544

31 March 2020

Long-term follow-up of patients with papillary and follicular thyroid cancer: a prospective study on 715 patients

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.544

31 March 2020

Hürthle cell carcinoma of the thyroid gland: prognostic factors and results of surgical treatment

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.544

31 March 2020

Modeling metastasis in the mouse

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.544

31 March 2020

Metastasis of human tumors in athymic nude mice

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.544

31 March 2020

Epidermal growth factor receptor as a novel therapeutic target in anaplastic thyroid carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.544

31 March 2020

Tumor vascularity predicts recurrence in differentiated thyroid carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.544

31 March 2020

1,25-Dihydroxycholecalciferol (1,25-D3) inhibits the growth of squamous cell carcinoma and down-modulates p21(Waf1/Cip1) in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/24362526

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/ONC.2013.544

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24362526%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24362526%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24362526%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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