STAT proteins as novel targets for cancer drug discovery (Q35911116)

11 August 2017

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title

STAT proteins as novel targets for cancer drug discovery (English)

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11 August 2017

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James Turkson

1

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PubMed ID

15469392

11 August 2017

language of work or name

English

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publication date

1 October 2004

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Expert Opinion on Therapeutic Targets

11 August 2017

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11 August 2017

8

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11 August 2017

409-422

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11 August 2017

5

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STATs and gene regulation

11 August 2017

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https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

The role of STATs in transcriptional control and their impact on cellular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

How cells respond to interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Control of myeloid differentiation and survival by Stats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Roles of STAT3 defined by tissue-specific gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

The STATs of cancer--new molecular targets come of age

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.5.409

STAT proteins: novel molecular targets for cancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Stat3 plays an important role in oncogenic Ros- and insulin-like growth factor I receptor-induced anchorage-independent growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Kinase activation of the non-receptor tyrosine kinase Etk/BMX alone is sufficient to transactivate STAT-mediated gene expression in salivary and lung epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Constitutive activation of Jak/STAT proteins in Epstein-Barr virus-infected B-cell lines from patients with posttransplant lymphoproliferative disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Functional roles of STAT family proteins: lessons from knockout mice

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.5.409

STAT signaling in head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

The role of STATs in myeloid differentiation and leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

STAT signaling in the pathogenesis and treatment of leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Untangling the ErbB signalling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Autocrine stimulation of human mammary carcinoma cell proliferation by human growth hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

An unexpected biochemical and functional interaction between gp130 and the EGF receptor family in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Differential function of STAT5 isoforms in head and neck cancer growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Epidermal growth factor receptor--mediated stat3 signaling blocks apoptosis in head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Signal transducer and activator of transcription-3 and phosphatidylinositol-3 kinase as coordinate regulators of melanoma cell response to glucocorticoid hormones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Signalling by the oncogenic receptor tyrosine kinase Xmrk leads to activation of STAT5 in Xiphophorus melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Stat3 activation in prostatic carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

IL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Interleukin-6 and prostate cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway .

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Constitutive activation of Stat3alpha in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Retinoic acid increases proliferation rate of GL-15 glioma cells, involving activation of STAT-3 transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Constitutive activation of STAT transcription factors in acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Constitutive activation of STAT3 and STAT5 is induced by leukemic fusion proteins with protein tyrosine kinase activity and is sufficient for transformation of hematopoietic precursor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Interleukin-6 acts as an antiapoptotic factor in human esophageal carcinoma cells through the activation of both STAT3 and mitogen-activated protein kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI 3-K/Akt pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Constitutive activation of stat 3 oncogene product in human ovarian carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

A Stat3-interacting protein (StIP1) regulates cytokine signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Modulation of STAT signaling by STAT-interacting proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Negative regulation of cytokine signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

SOCS proteins, regulators of intracellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

The STAT family of proteins in cytokine signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Three-dimensional structure of the Stat3beta homodimer bound to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Identification of a high-affinity phosphopeptide inhibitor of Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.5.409

21 January 2018

Identifiers

DOI

10.1517/14728222.8.5.409

1 reference

11 August 2017

1 reference

PubMed ID

15469392