Dermal delivery of HSP47 siRNA with NOX4-modulating mesoporous silica-based nanoparticles for treating fibrosis. (Q35908995)

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19 February 2020

title

Dermal delivery of HSP47 siRNA with NOX4-modulating mesoporous silica-based nanoparticles for treating fibrosis (English)

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19 February 2020

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3

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19 February 2020

author name string

Jingga Morry

1

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19 February 2020

Worapol Ngamcherdtrakul

2

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19 February 2020

Shaun M Goodyear

4

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19 February 2020

David J Castro

5

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19 February 2020

Moataz M Reda

6

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19 February 2020

Thanapon Sangvanich

7

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19 February 2020

Wassana Yantasee

8

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19 February 2020

publication date

10 July 2015

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19 February 2020

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19 February 2020

volume

66

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19 February 2020

page(s)

41-52

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Cationic Polymer Modified Mesoporous Silica Nanoparticles for Targeted SiRNA Delivery to HER2+ Breast Cancer

19 February 2020

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New insights into the role of oxidative stress in scleroderma fibrosis.

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Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo.

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Integrating mechanisms of pulmonary fibrosis

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Immune response to extracellular matrix collagen in chronic hepatitis C-induced liver fibrosis

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Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases

11 July 2018

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TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells.

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NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFbeta1-induced fibroblast differentiation into myofibroblasts.

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11 July 2018

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First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder.

11 July 2018

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11 July 2018

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NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury.

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma

11 July 2018

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11 July 2018

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Induction of heat shock protein 47 synthesis by TGF-beta and IL-1 beta via enhancement of the heat shock element binding activity of heat shock transcription factor 1

11 July 2018

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Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway

11 July 2018

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11 July 2018

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A reactive oxygen species-mediated loop maintains increased expression of NADPH oxidases 2 and 4 in skin fibroblasts from patients with systemic sclerosis.

11 July 2018

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12 December 2020

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Hsp47 as a collagen-specific molecular chaperone

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Multistage Mesoporous Silicon-based Nanocarriers: Biocompatibility with Immune Cells and Controlled Degradation in Physiological Fluids

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Increased expression of heat-shock protein 47 is associated with overproduction of type I procollagen in systemic sclerosis skin fibroblasts

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10.1016/J.BIOMATERIALS.2015.07.005

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26196532%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26196532%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

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