Microenvironmental and cellular consequences of altered blood flow in tumours (Q35904989)

11 August 2017

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title

Microenvironmental and cellular consequences of altered blood flow in tumours (English)

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11 August 2017

Raghunand N

1

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11 August 2017

Gatenby RA

series ordinal

2

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11 August 2017

Gillies RJ

series ordinal

3

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11 August 2017

language of work or name

English

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publication date

1 January 2003

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British Journal of Radiology

11 August 2017

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11 August 2017

76 Spec No 1

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11 August 2017

S11-22

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Vascular-specific growth factors and blood vessel formation

11 August 2017

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Measuring tumour vascular response to antivascular and antiangiogenic drugs

21 January 2018

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Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications

21 January 2018

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

21 January 2018

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Angiogenesis in cancer and other diseases

21 January 2018

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A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR.

21 January 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

21 January 2018

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

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Concepts of oxygen transport at the microcirculatory level.

21 January 2018

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Role of incipient angiogenesis in cancer metastasis

21 January 2018

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https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Delivery of molecular and cellular medicine to solid tumors

21 January 2018

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https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Theoretical models for drug delivery to solid tumors.

21 January 2018

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https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Blood perfusion measurements in human tumours: evaluation of laser Doppler methods

21 January 2018

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The histological structure of some human lung cancers and the possible implications for radiotherapy

21 January 2018

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The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer

21 January 2018

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The relevance of tumour pH to the treatment of malignant disease

21 January 2018

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Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

21 January 2018

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https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

21 January 2018

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https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Downmodulation of bFGF-binding protein expression following restoration of p53 function

21 January 2018

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https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

21 January 2018

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Microenvironment-induced cancer metastasis

21 January 2018

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The urokinase-type plasminogen activator system in cancer metastasis: a review

21 January 2018

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Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: involvement of microvascular hot spots induced in hypoxic foci by interleukin 8.

21 January 2018

1 reference

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Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Gadolinium(III) texaphyrin: a tumor selective radiation sensitizer that is detectable by MRI.

21 January 2018

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https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Bioreductive and gene therapy approaches to hypoxic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiological conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Increased release of tumour cells by collagenase at acid pH: a possible mechanism for metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Cathepsin B and its endogenous inhibitors: the role in tumor malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Alterations in proteolytic activity at low pH and its association with invasion: a theoretical model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Urokinase plasminogen activator: a prognostic marker in multiple types of cancer

21 January 2018

1 reference

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Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin L

21 January 2018

1 reference

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Secreted cathepsin L generates endostatin from collagen XVIII

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Acidic pH enhances the invasive behavior of human melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Heparan sulfate degradation: relation to tumor invasive and metastatic properties of mouse B16 melanoma sublines

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Molecular behavior adapts to context: heparanase functions as an extracellular matrix-degrading enzyme or as a T cell adhesion molecule, depending on the local pH.

21 January 2018

1 reference

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Human heparanase. Purification, characterization, cloning, and expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Enhancement of chemotherapy by manipulation of tumour pH.

21 January 2018

1 reference

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Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone

21 January 2018

1 reference

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Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro

21 January 2018

1 reference

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Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents

21 January 2018

1 reference

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Acidosis plus melphalan induces nitric oxide-mediated tumor regression in an isolated limb perfusion human melanoma xenograft model

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

pH and drug resistance in tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix

21 January 2018

1 reference

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Cooperation and competition in the evolution of ATP-producing pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Glucose transporter 1 gene expression is related to thyroid neoplasms with an unfavorable prognosis: an immunohistochemical study

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Expression of glucose transporter-1 in human gastric carcinoma: association with tumor aggressiveness, metastasis, and patient survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Expression of glucose transporter-1 in cervical cancer and its precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Glut3 expression in biopsy specimens of laryngeal carcinoma is associated with poor survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Glucose utilization by intracranial meningiomas as an index of tumor aggressivity and probability of recurrence: a PET study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

The role of positron emission tomography in oncology and other whole-body applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Expression of hexokinase II and Glut-1 in untreated human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Glycolysis as a metabolic marker in orthotopic breast cancer, monitored by in vivo (13)C MRS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

MicroPET assessment of androgenic control of glucose and acetate uptake in the rat prostate and a prostate cancer tumor model

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Differential uptake of (18)F-fluorodeoxyglucose by experimental tumors xenografted into immunocompetent and immunodeficient mice and the effect of immunomodification

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

21 January 2018

Are cancer cells acidic?

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Cytostatic potential of novel agents that inhibit the regulation of intracellular pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

The quest by three giants of science for an understanding of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Genome changes and gene expression in human solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Lineage selection and the evolution of multistage carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Tumor micro-ecology and competitive interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

A cellular automaton model of early tumor growth and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Acidic environment causes apoptosis by increasing caspase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix

21 January 2018

1 reference

https://api.crossref.org/works/10.1259%2FBJR%2F12913493

21 January 2018

Identifiers

DOI

10.1259/BJR/12913493

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11 August 2017

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