A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface (Q35886917)

10 August 2017

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface (English)

1 reference

10 August 2017

1

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10 June 2020

Simone C Oostindie

9

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10 June 2020

Albert J.R. Heck

11

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10 June 2020

Paul Whi Parren

13

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10 June 2020

author name string

Frank J Beurskens

2

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10 June 2020

Sandra Verploegen

3

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10 June 2020

Kristin Strumane

4

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10 June 2020

Muriel D van Kampen

5

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10 June 2020

Marleen Voorhorst

6

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10 June 2020

Wendy Horstman

7

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10 June 2020

Patrick J Engelberts

8

1 reference

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10 June 2020

Guanbo Wang

10

1 reference

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10 June 2020

Janine Schuurman

12

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10 June 2020

language of work or name

English

0 references

publication date

6 January 2016

1 reference

10 August 2017

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10 June 2020

volume

14

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10 June 2020

issue

1

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10 June 2020

page(s)

e1002344

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Creative Commons Attribution 4.0 International

10 June 2020

copyright license

start time

6 January 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Complement is activated by IgG hexamers assembled at the cell surface

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Chemical and Structural Analysis of an Antibody Folding Intermediate Trapped during Glycan Biosynthesis

11 July 2018

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Revisiting the role of glycosylation in the structure of human IgG Fc.

11 July 2018

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Effect of zinc on human IgG1 and its FcγR interactions

11 July 2018

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Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

11 July 2018

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Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors.

11 July 2018

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Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity

11 July 2018

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Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions

11 July 2018

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Binding of submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): considerably higher levels of CDC are induced by OFA than by RTX.

11 July 2018

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Native mass spectrometry: a bridge between interactomics and structural biology

11 July 2018

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Optimization of antibody binding to FcgammaRIIa enhances macrophage phagocytosis of tumor cells

11 July 2018

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Modulation of the effector functions of a human IgG1 through engineering of its hinge region

11 July 2018

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Engineered antibody Fc variants with enhanced effector function

11 July 2018

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Dual mode of action of a human anti-epidermal growth factor receptor monoclonal antibody for cancer therapy

11 July 2018

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Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

11 July 2018

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Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity

11 July 2018

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Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts

11 July 2018

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Differential activation of human and guinea pig complement by pentameric and hexameric IgM.

11 July 2018

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Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

11 July 2018

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Engineered antibodies with increased activity to recruit complement

11 July 2018

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11 July 2018

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Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc

11 July 2018

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Convergent solutions to binding at a protein-protein interface

11 July 2018

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The immunoglobulin fold family: sequence analysis and 3D structure comparisons

11 July 2018

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Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody

11 July 2018

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Addition of a mu-tailpiece to IgG results in polymeric antibodies with enhanced effector functions including complement-mediated cytolysis by IgG4.

11 July 2018

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Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma

11 July 2018

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Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement

11 July 2018

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Humanized monoclonal antibody CAMPATH-1H: myeloma cell expression of genomic constructs, nucleotide sequence of cDNA constructs and comparison of effector mechanisms of myeloma and Chinese hamster ovary cell-derived material

11 July 2018

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The structure and function of immunoglobulin domains. II. The importance of interchain disulfide bonds and the possible role of molecular flexibility in the interaction between immunoglobulin G and complement

11 July 2018

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Evaluation of electrospray ionization mass spectrometry as a tool for characterization of small soluble protein aggregates

11 July 2018

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Epidermal growth factor receptor (EGFR) antibody-induced antibody-dependent cellular cytotoxicity plays a prominent role in inhibiting tumorigenesis, even of tumor cells insensitive to EGFR signaling inhibition.

24 September 2018

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Structural difference in the complement activation site of human IgG1 and IgG3.

24 September 2018

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High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

24 September 2018

1 reference

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Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies

24 September 2018

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Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

21 January 2018

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The effect of the source pressure on the abundance of ions of noncovalent protein assemblies in an electrospray ionization orthogonal time-of-flight instrument

21 January 2018

1 reference

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Improving the Performance of a Quadrupole Time-of-Flight Instrument for Macromolecular Mass Spectrometry

21 January 2018

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Is IgM-like dislocation a common feature of antibody function?

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/26736041

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Specific interactions in high concentration antibody solutions resulting in high viscosity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26736041

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PBIO.1002344

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26736041%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26736041%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26736041%20AND%20SRC:MED&resulttype=core&format=json