Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A (Q35879542)

10 August 2017

Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A (English)

1 reference

10 August 2017

1 reference

Marco Genua

2

0 references

Jiří Jiráček

object named as

Jiri Jiracek

5

0 references

Antonino Belfiore

object named as

Antonino Belfiore

8

0 references

Renato V. Iozzo

object named as

Renato V Iozzo

7

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author name string

Alaide Morcavallo

1

1 reference

10 August 2017

Angela Palummo

3

1 reference

10 August 2017

Emilia Kletvikova

4

1 reference

10 August 2017

Andrzej M Brzozowski

6

1 reference

10 August 2017

Andrea Morrione

9

1 reference

10 August 2017

language of work or name

English

0 references

publication date

8 February 2012

1 reference

10 August 2017

15

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

10 August 2017

287

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10 August 2017

14

1 reference

10 August 2017

11422-11436

1 reference

describes a project that uses

10 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3322853/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Insulin X10 revisited: a super-mitogenic insulin analogue

11 July 2018

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The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin

11 July 2018

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Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues

11 July 2018

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Pathways and mechanisms of endocytic recycling

11 July 2018

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Rapid insulin-dependent endocytosis of the insulin receptor by caveolae in primary adipocytes

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Inhibitors of clathrin-dependent endocytosis enhance TGFbeta signaling and responses

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Differential signaling activation by insulin and insulin-like growth factors I and II upon binding to insulin receptor isoform A.

11 July 2018

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Proepithelin is an autocrine growth factor for bladder cancer

11 July 2018

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Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor

11 July 2018

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11 July 2018

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Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization

11 July 2018

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Structural basis for the lower affinity of the insulin-like growth factors for the insulin receptor

11 July 2018

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EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate

11 July 2018

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The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer.

11 July 2018

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Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation

11 July 2018

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Clathrin-independent endocytosis of ubiquitinated cargos

11 July 2018

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Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

11 July 2018

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Insulin and hybrid insulin/IGF receptors are major regulators of breast cancer cells.

11 July 2018

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Endocytosis and cancer.

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Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

11 July 2018

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The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor

11 July 2018

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Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit

11 July 2018

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IRS proteins and the common path to diabetes

11 July 2018

1 reference

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Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

11 July 2018

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When cell biology meets development: endocytic regulation of signaling pathways

11 July 2018

1 reference

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Endocytosis and signaling. an inseparable partnership

11 July 2018

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A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

11 July 2018

1 reference

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Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition

11 July 2018

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Localization of the insulin receptor in caveolae of adipocyte plasma membrane

11 July 2018

1 reference

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mGrb10 interacts with Nedd4

11 July 2018

1 reference

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Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

11 July 2018

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The IRS-signalling system: a network of docking proteins that mediate insulin action

11 July 2018

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Differential effects of Wilms tumor WT1 splice variants on the insulin receptor promoter

11 July 2018

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Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma

11 July 2018

1 reference

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The role of mGrb10alpha in insulin-like growth factor I-mediated growth

11 July 2018

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Insulin-like growth factor II stimulates cell proliferation through the insulin receptor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

ASPB10 insulin induction of increased mitogenic responses and phenotypic changes in human breast epithelial cells: evidence for enhanced interactions with the insulin-like growth factor-I receptor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Ligand-binding properties of the two isoforms of the human insulin receptor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Effect of dexamethasone on the alternative splicing of the insulin receptor mRNA and insulin action in HepG2 hepatoma cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts

11 July 2018

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Different Effects on Mitogenesis and Transformation of a Mutation at Tyrosine 1251 of the Insulin-like Growth Factor I Receptor

11 July 2018

1 reference

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Interpretation of binding curves obtained with high receptor concentrations: practical aid for computer analysis

11 July 2018

1 reference

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Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Receptor-mediated endocytosis of insulin: role of microvilli, coated pits, and coated vesicles

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Evidence for two independent pathways of insulin-receptor internalization in hepatocytes and hepatoma cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Functionally distinct insulin receptors generated by tissue-specific alternative splicing

11 July 2018

1 reference

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The insulin-like growth factor family of ligands, receptors, and binding proteins

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Differential endocytosis and signaling dynamics of insulin receptor variants IR-A and IR-B.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Comparison of the intracellular itineraries of insulin-like growth factor-I and insulin and their receptors in Rat-1 fibroblasts

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Alternative splicing of human insulin receptor messenger RNA.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322853

Absence of down-regulation of insulin receptors in human breast cancer cells (MCF-7) cultured in serum-free medium: comparison with epidermal growth factor

24 September 2018

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12 December 2020

Internalization of the human insulin receptor. The insulin-independent pathway

1 reference

12 December 2020

Abnormal insulin-receptor down regulation and dissociation of down regulation from insulin biological action in cultured human tumor cells

1 reference

12 December 2020

Proepithelin Promotes Migration and Invasion of 5637 Bladder Cancer Cells through the Activation of ERK1/2 and the Formation of a Paxillin/FAK/ERK Complex

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M111.252478

1 reference

10 August 2017

1 reference

10 August 2017

PubMed publication ID

22318726

1 reference