Differences in drug pharmacokinetics between East Asians and Caucasians and the role of genetic polymorphisms (Q35876954)

10 August 2017

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title

Differences in drug pharmacokinetics between East Asians and Caucasians and the role of genetic polymorphisms (English)

1 reference

10 August 2017

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3

Hartmut Derendorf

1 reference

10 August 2017

Kiman Kim

1

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PubMed ID

15342610

10 August 2017

Julie A Johnson

series ordinal

2

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10 August 2017

1 October 2004

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The Journal of Clinical Pharmacology

10 August 2017

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10 August 2017

44

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10 August 2017

1083-1105

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10 August 2017

10

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Contribution of Environmental Factors to Variability in Human Drug Metabolism

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Environmental factors affecting antipyrine metabolism in London factory and office workers

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Antipyrene clearance in Indian villagers

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Ethnicity and antipsychotic response

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Drug, meal and formulation interactions influencing drug absorption after oral administration. Clinical implications

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Effects of some compounds isolated from Chinese medicinal herbs on hepatic microsomal cytochrome P-450 and their potential biological consequences

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The effects of diet, aging and disease-states on presystemic elimination and oral drug bioavailability in humans

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Pharmacogenetics: an opportunity for a safer and more efficient pharmacotherapy

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Pharmacogenomics: translating functional genomics into rational therapeutics

21 January 2018

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Pharmacogenomics: the inherited basis for interindividual differences in drug response

21 January 2018

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Pharmacogenomics: unlocking the human genome for better drug therapy

21 January 2018

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Pharmacogenomics--drug disposition, drug targets, and side effects

21 January 2018

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Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment

21 January 2018

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The evolution of drug metabolism

21 January 2018

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Science, medicine, and the future: Pharmacogenetics

21 January 2018

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Inheritance and drug response

21 January 2018

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Differences in drug metabolism polymorphism between Orientals and Caucasians

21 January 2018

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Interethnic variation of drug metabolism

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Ethnic differences in drug disposition and responsiveness

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19

21 January 2018

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Molecular basis of polymorphic drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Ethnic differences in drug disposition and response.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Culture and psychopharmacology

21 January 2018

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Racial differences in the response to drugs--pointers to genetic differences

21 January 2018

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Molecular basis of ethnic differences in drug disposition and response

21 January 2018

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A review and assessment of potential sources of ethnic differences in drug responsiveness

21 January 2018

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The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

21 January 2018

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Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier

21 January 2018

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P-Glycoprotein in clinical cardiology.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions

21 January 2018

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The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans

21 January 2018

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Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

21 January 2018

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Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Identification of functionally variant MDR1 alleles among European Americans and African Americans

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Frequency of C3435T polymorphism of MDR1 gene in African people

21 January 2018

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Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study

21 January 2018

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Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.

21 January 2018

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Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients

21 January 2018

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Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

21 January 2018

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Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

21 January 2018

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The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine

21 January 2018

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Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine

21 January 2018

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C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation

21 January 2018

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Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics

21 January 2018

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Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

21 January 2018

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Interaction of citrus juices with felodipine and nifedipine

21 January 2018

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Interaction between grapefruit juice and midazolam in humans.

21 January 2018

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Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice.

21 January 2018

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Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

21 January 2018

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Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man

21 January 2018

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Grapefruit juice-drug interactions

21 January 2018

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Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid

21 January 2018

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Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors

21 January 2018

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Grapefruit juice substantially increases plasma concentrations of buspirone

21 January 2018

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Influence of dietary components on the gastrointestinal metabolism and transport of drugs

21 January 2018

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Drug-grapefruit juice interactions

21 January 2018

1 reference

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Dramatic inhibition of amiodarone metabolism induced by grapefruit juice

21 January 2018

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Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice

21 January 2018

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Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol

21 January 2018

1 reference

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Intestinal drug efflux: formulation and food effects

21 January 2018

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The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein

21 January 2018

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Effects of grapefruit juice and smoking on verapamil concentrations in steady state

21 January 2018

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Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice

21 January 2018

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Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Influence of race or ethnicity on pharmacokinetics of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

21 January 2018

1 reference

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Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

21 January 2018

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Frequency of C3435T single nucleotide MDR1 genetic polymorphism in an Asian population: phenotypic-genotypic correlates

21 January 2018

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Differences in calcium absorption and kinetics between black and white girls aged 5-16 years

21 January 2018

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Racial variation in dosage requirements of tacrolimus

21 January 2018

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Gender-dependent racial difference in disposition of cyclosporine among healthy African American and white volunteers

21 January 2018

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The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups

21 January 2018

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Drug binding in plasma. A summary of recent trends in the study of drug and hormone binding

21 January 2018

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Differences between blacks and whites in plasma protein binding of drugs.

21 January 2018

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Differences in plasma binding of drugs between Caucasians and Chinese subjects.

21 January 2018

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Evidence for differences in the binding of drugs to the two main genetic variants of human alpha 1-acid glycoprotein

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Racial differences in drug response. Altered sensitivity to and clearance of propranolol in men of Chinese descent as compared with American whites

21 January 2018

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Diphenhydramine in Orientals and Caucasians

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression

21 January 2018

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Pharmacokinetics of reboxetine in healthy volunteers. Single oral doses, linearity and plasma protein binding

21 January 2018

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Pharmacokinetics of reboxetine in healthy volunteers with different ethnic descents

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

"It's the genes, stupid". Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism

21 January 2018

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Impact of P450 genetic polymorphism on the first-pass extraction of cardiovascular and neuroactive drugs

21 January 2018

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Pharmacogenomics and schizophrenia

21 January 2018

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Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs

21 January 2018

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Molecular mechanisms of genetic polymorphisms of drug metabolism

21 January 2018

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Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

21 January 2018

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Effect of the CYP2D6*10 genotype on venlafaxine pharmacokinetics in healthy adult volunteers

21 January 2018

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The impact of the CYP2D6 and CYP2C19 genotypes on venlafaxine pharmacokinetics in a Japanese population

21 January 2018

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Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O-demethylation in different CYP2D6 genotypes

21 January 2018

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Risperidone metabolism in relation to CYP2D6*10 allele in Korean schizophrenic patients

21 January 2018

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Effect of the CYP2D6 genotype on the pharmacokinetics of tropisetron in healthy Korean subjects.

21 January 2018

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Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6.

21 January 2018

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Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite: relationship to the CYP2D6 genotype.

21 January 2018

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Plasma concentrations of haloperidol are related to CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients

21 January 2018

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A longitudinal assessment of haloperidol doses and serum concentrations in Asian and Caucasian schizophrenic patients

21 January 2018

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Asian/non-Asian transcultural tricyclic antidepressant psychopharmacology: a review

21 January 2018

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An investigation of ethnic and gender differences in the pharmacodynamics of haloperidol.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Interindividual and interethnic differences in the demethylation and glucuronidation of codeine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Pharmacokinetics of codeine and its metabolites in Caucasian healthy volunteers: comparisons between extensive and poor hydroxylators of debrisoquine

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Formation of morphine from codeine in Chinese subjects of different CYP2D6 genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

A comparison of the pharmacokinetics of codeine and its metabolites in healthy Chinese and Caucasian extensive hydroxylators of debrisoquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Desipramine pharmacokinetics in Chinese and Caucasian volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Genetic polymorphism of drug metabolising enzymes in African populations: implications for the use of neuroleptics and antidepressants

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Biochemistry and molecular biology of the human CYP2C subfamily

21 January 2018

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Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Clinical relevance of genetic polymorphisms in the human CYP2C subfamily

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270004268128

Genetic polymorphism of S-mephenytoin hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.

21 January 2018

1 reference

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Pharmacokinetics and effect on caffeine metabolism of the proton pump inhibitors, omeprazole, lansoprazole, and pantoprazole

21 January 2018

1 reference

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Pharmacogenetics and psychopharmacotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Pharmacodynamic effects and kinetic disposition of rabeprazole in relation to CYP2C19 genotypes

21 January 2018

1 reference

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Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Clinical significance of the cytochrome P450 2C19 genetic polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

The role of CYP2C19 in amitriptyline N-demethylation in Chinese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Interphenotype differences in disposition and effect on gastrin levels of omeprazole--suitability of omeprazole as a probe for CYP2C19

21 January 2018

1 reference

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Ethnic and genetic determinants of omeprazole disposition and effect.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Differences in diazepam pharmacokinetics in Chinese and white Caucasians--relation to body lipid stores.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Diazepam effects and kinetics in Caucasians and Orientals

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: interethnic differences in comparison with white subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Why are diazepam metabolism and polymorphic S-mephenytoin hydroxylation associated with each other in white and Korean populations but not in Chinese populations?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

P-hydroxylation of phenobarbital: relationship to (S)-mephenytoin hydroxylation (CYP2C19) polymorphism

21 January 2018

1 reference

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Genetic polymorphism of mephenytoin p(4')-hydroxylation: difference between Orientals and Caucasians

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Genetic variations of S-mephenytoin 4'-hydroxylase (CYP2C19) in the Chinese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Human P450 metabolism of warfarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Clinical relevance of genetic polymorphisms in the human CYP2C9 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

A common genetic basis for idiosyncratic toxicity of warfarin and phenytoin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Interindividual variability in sensitivity to warfarin--Nature or nurture?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Pharmacogenetics of warfarin elimination and its clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

CYP2C9 polymorphism and warfarin dose requirements

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Warfarin dose adjustments based on CYP2C9 genetic polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Altered pharmacokinetics of R- and S-acenocoumarol in a subject heterozygous for CYP2C9*3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Frequency of cytochrome P450 2C9 mutant alleles in a Korean population

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

CYP2C9 polymorphism: impact on tolbutamide pharmacokinetics and response

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Acenocoumarol pharmacokinetics in relation to cytochrome P450 2C9 genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Influence of CYP2C9 polymorphisms on the pharmacokinetics and cholesterol-lowering activity of (-)-3S,5R-fluvastatin and (+)-3R,5S-fluvastatin in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Factors determining the maintenance dose of warfarin in Chinese patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Pharmacokinetics of tolbutamide in ethnic Chinese

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

CYP2C9 allelic variants: ethnic distribution and functional significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Genetic polymorphisms of CYP2C9 and CYP2C19 in the Beninese and Belgian populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Genetic polymorphism of cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Analysis of CYP2C9*5 in Caucasian, Oriental and black-African populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Genetic polymorphism in exon 4 of cytochrome P450 CYP2C9 may be associated with warfarin sensitivity in Chinese patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Population differences in S-warfarin metabolism between CYP2C9 genotype-matched Caucasian and Japanese patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

CYP3A gene expression in human gut epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

In vitro and in vivo drug interactions involving human CYP3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Cytochrome P450 3A: ontogeny and drug disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Cytochrome P-450 3A4: regulation and role in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Factors affecting the clinical development of cytochrome p450 3A substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Genetic contribution to variable human CYP3A-mediated metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4*1B5'-promoter region polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Identification and functional characterization of eight CYP3A4 protein variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Expression of cytochrome P450 3A in amphibian, rat, and human kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Pharmacokinetics of midazolam and 1'-hydroxymidazolam in Chinese with different CYP3A5 genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

CYP3A5 genotype did not impact on nifedipine disposition in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

The increase in urinary excretion of 6 beta-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Newer antidepressants and the cytochrome P450 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

A kinetic and dynamic study of oral alprazolam with and without erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in alprazolam metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Alprazolam is another substrate for human cytochrome P450-3A isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Ethnic differences and relationships in the oral pharmacokinetics of nifedipine and erythromycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Ethnic differences in the pharmacokinetics of oral nifedipine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Factors affecting the absolute bioavailability of nifedipine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Midazolam is metabolized by at least three different cytochrome P450 enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Nifedipine kinetics and bioavailability after single intravenous and oral doses in normal subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

The first pass metabolism of nifedipine in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Pharmacokinetics of repaglinide in healthy caucasian and Japanese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Inter-ethnic comparisons of the pharmacokinetics of the HMG-CoA reductase inhibitor cerivastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

CYP3A activity in European American and Japanese men using midazolam as an in vivo probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Fluvoxamine Inhibition and Carbamazepine Induction of the Metabolism of Clozapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

CYP2A6: a human coumarin 7-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

The significance of the homozygous CYP2A6 deletion on nicotine metabolism: a new genotyping method of CYP2A6 using a single PCR-RFLP

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Nicotine metabolism defect reduces smoking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Genetic variation of CYP2A6, smoking, and risk of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Nicotine metabolism varies between different ethnic groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Slower metabolism and reduced intake of nicotine from cigarette smoking in Chinese-Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Structural characterization of a new variant of the CYP2A6 gene (CYP2A6*1B) apparently diagnosed as heterozygotes of CYP2A6*1A and CYP2A6*4C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Genetic polymorphism of CYP2A6 in the German population

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Nicotine metabolism and CYP2A6 allele frequencies in Koreans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Polymorphisms of CYP2A6 and its practical consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

CYP2A6 genetic polymorphisms and liver microsomal coumarin and nicotine oxidation activities in Japanese and Caucasians

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene: impairment of its promoter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Triazolam pharmacokinetics and pharmacodynamics in Caucasians and Southern Asians: ethnicity and CYP3A activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

The Effect of CYP3A5 and MDR1 Polymorphic Expression on Cyclosporine Oral Disposition in Renal Transplant Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004268128

21 January 2018

Identifiers

DOI

10.1177/0091270004268128

1 reference

10 August 2017

1 reference

PubMed ID

15342610