The biological and clinical significance of MLL abnormalities in haematological malignancies (Q35854955)

10 August 2017

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title

The biological and clinical significance of MLL abnormalities in haematological malignancies (English)

1 reference

10 August 2017

G Mitterbauer-Hohendanner

series ordinal

1

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PubMed ID

15291802

10 August 2017

C Mannhalter

series ordinal

2

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10 August 2017

1 August 2004

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European Journal of Clinical Investigation

10 August 2017

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10 August 2017

34 Suppl 2

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10 August 2017

12-24

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The role of MLL in hematopoiesis and leukemia

10 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

The structure of the human ALL-1/MLL/HRX gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Oncogenic transcription factors in the human acute leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Altered Hox expression and segmental identity in Mll-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Identification and characterization of a family of mammalian methyl-CpG binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

The bromodomain revisited.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Structure and ligand of a histone acetyltransferase bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

SET domain proteins modulate chromatin domains in eu- and heterochromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

A homeotic mutation in the trithorax SET domain impedes histone binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Exon/intron structure of the human AF-4 gene, a member of the AF-4/LAF-4/FMR-2 gene family coding for a nuclear protein with structural alterations in acute leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Hematologic malignancies with t(4;11)(q21;q23)--a cytogenetic, morphologic, immunophenotypic and clinical study of 183 cases. European 11q23 Workshop participants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Treatment of infants with lymphoblastic leukaemia: results of the UK Infant Protocols 1987-1999.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Clinico-biologic features and treatment outcome of adult pro-B-ALL patients enrolled in the GIMEMA 0496 study: absence of the ALL1/AF4 and of the BCR/ABL fusion genes correlates with a significantly better clinical outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

The partial tandem duplication of ALL1 (MLL) is consistently generated by Alu-mediated homologous recombination in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

The partial tandem duplication of ALL1 in acute myeloid leukemia with normal cytogenetics or trisomy 11 is restricted to one chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Frequent chromosomal translocations induced by DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Multiplex reverse transcriptase-polymerase chain reaction screening in childhood acute myeloblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Identification of CBL, a proto‐oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

An ins(X;11)(q24;q23) fuses the MLL and the Septin 6/KIAA0128 gene in an infant with AML-M2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

Monitoring of minimal residual disease in patients with MLL-AF6-positive acute myeloid leukaemia by reverse transcriptase polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0960-135X.2004.01366.X

10.1111/J.0960-135X.2004.01366.X

21 January 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference

PubMed ID

15291802