Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma (Q35848973)

10 August 2017

Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma (English)

1 reference

Leticia Quintanilla-Martinez

10 August 2017

7

object named as

Leticia Quintanilla-Martinez

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Falko Fend

5

object named as

Falko Fend

0 references

Stefania Pittaluga

2

object named as

Stefania Pittaluga

1 reference

10 August 2017

6

Elaine S Jaffe

1 reference

10 August 2017

8

Mark Raffeld

1 reference

10 August 2017

1

Martina Rudelius

1 reference

10 August 2017

Satoshi Nishizuka

3

1 reference

10 August 2017

Trinh H-T Pham

4

1 reference

10 August 2017

language of work or name

English

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publication date

27 April 2006

1 reference

10 August 2017

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10 August 2017

108

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10 August 2017

1668-1676

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10 August 2017

5

1 reference

describes a project that uses

10 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1895501/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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27 July 2018

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Z-138 cell line was derived from a patient with blastoid variant mantle cell lymphoma

27 July 2018

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The Akt-mTOR tango and its relevance to cancer

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Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum.

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Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR.

27 July 2018

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Proteomic analysis of mantle-cell lymphoma by protein microarray

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Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma

27 July 2018

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The LKB1 tumor suppressor negatively regulates mTOR signaling

27 July 2018

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Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes.

27 July 2018

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The molecular target of rapamycin (mTOR) as a therapeutic target against cancer

27 July 2018

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Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

27 July 2018

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United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

27 July 2018

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Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

27 July 2018

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

27 July 2018

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

27 July 2018

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Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

27 July 2018

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The phosphoinositide 3-kinase pathway

27 July 2018

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The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation

27 July 2018

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

27 July 2018

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Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front

27 July 2018

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Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.

27 July 2018

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Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation

27 July 2018

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Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

27 July 2018

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BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival

27 July 2018

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Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene

27 July 2018

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

27 July 2018

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

27 July 2018

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Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells

27 July 2018

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BCL-2 family members and the mitochondria in apoptosis

27 July 2018

1 reference

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Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

27 July 2018

1 reference

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Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations.

27 July 2018

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Analysis of PTEN mutations and deletions in B-cell non-Hodgkin's lymphomas.

27 July 2018

1 reference

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PTEN gene alterations in lymphoid neoplasms

27 July 2018

1 reference

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

27 July 2018

1 reference

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A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Potential role for concurrent abnormalities of the cyclin D1, p16CDKN2 and p15CDKN2B genes in certain B cell non-Hodgkin's lymphomas. Functional studies in a cell line (Granta 519).

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

27 July 2018

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Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

27 July 2018

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

27 July 2018

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Characterization of a new non-Hodgkin's lymphoma cell line (NCEB-1) with a chromosomal (11:14) translocation [t(11:14)(q13;q32)]

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Cloning of the t(11;14)(q13;q32) translocation breakpoints from two human leukemia cell lines.

27 July 2018

1 reference

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Akt-regulated pathways in prostate cancer

27 July 2018

1 reference

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Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia: frequent PIK3CA amplification and AKT phosphorylation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

The PIK3CA gene is mutated with high frequency in human breast cancers.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

TSC2 mediates cellular energy response to control cell growth and survival

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Germline Inactivation of PTEN and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway Cause Human Lhermitte-Duclos Disease in Adults

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Cell cycle alterations in the blastoid variant of mantle cell lymphoma (MCL-BV) as detected by gene expression profiling of mantle cell lymphoma (MCL) and MCL-BV.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Blastic variant of mantle cell lymphoma: a rare but highly aggressive subtype

24 September 2018

1 reference

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PIK3CA is implicated as an oncogene in ovarian cancer.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

PTEN/MMAC1/TEP1 involvement in primary prostate cancers.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Mantle cell lymphoma: presenting features, response to therapy, and prognostic factors.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

p53 gene mutations and protein overexpression are associated with aggressive variants of mantle cell lymphomas

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Uncommon Mutation, but Common Amplifications, of thePIK3CAGene in Thyroid Tumors

14 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

14 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895501

Oncogenic mutations of PIK3CA in human cancers

14 November 2018

1 reference

12 December 2020

The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma

1 reference

12 December 2020

Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11 ; 14) chromosome translocation

1 reference

12 December 2020

bcl-1, t(11;14), and mantle cell-derived lymphomas

1 reference

12 December 2020

3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth

1 reference

12 December 2020

Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray

1 reference

12 December 2020

p53 overexpression as a marker of poor prognosis in mantle cell lymphomas with t(11;14)(q13;q32)

1 reference

12 December 2020

Apoptosis meets signal transduction: elimination of a BAD influence

1 reference

12 December 2020

Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the major translocation cluster region and tetraploid chromosome clones

1 reference

12 December 2020

Mantle cell lymphoma: a clinicopathologic study of 80 cases

1 reference

12 December 2020

p16(INK4a) gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin's lymphomas

1 reference

12 December 2020

Alterations of the MMAC1/PTEN gene in lymphoid malignancies

1 reference

12 December 2020

10.1182/BLOOD-2006-04-015586

Identifiers

DOI

1 reference

release_sz27iqtnivdufmzyngi2vmefr4

10 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/sz27iqtnivdufmzyngi2vmefr4

24 November 2022

mapped directly with Wikidata item

1 reference

10 August 2017

1 reference