Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor (Q35847470)

10 August 2017

Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor (English)

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Colony stimulating factor 2

10 August 2017

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Rebecca J Chan

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10 August 2017

Melissa B Leedy

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10 August 2017

Veerendra Munugalavadla

3

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10 August 2017

Cara S Voorhorst

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10 August 2017

Yanjun Li

5

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10 August 2017

Menggang Yu

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10 August 2017

Reuben Kapur

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10 August 2017

language of work or name

English

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publication date

11 January 2005

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10 August 2017

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10 August 2017

105

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10 August 2017

9

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10 August 2017

3737-3742

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describes a project that uses

10 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1895012/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

1 reference

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JAKs, STATs and Src kinases in hematopoiesis

11 July 2018

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PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity

11 July 2018

1 reference

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Molecular interactions of SHP1 and SHP2 in IL-3-signalling

11 July 2018

1 reference

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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

11 July 2018

1 reference

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Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase

11 July 2018

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Nf1 and Gmcsf interact in myeloid leukemogenesis

11 July 2018

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Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

11 July 2018

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Juvenile myelomonocytic leukemia and Noonan syndrome

11 July 2018

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Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.

11 July 2018

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Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines

11 July 2018

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Crystal structure of the tyrosine phosphatase SHP-2

11 July 2018

1 reference

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Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor

11 July 2018

1 reference

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Mutations of the RAS genes in childhood acute myeloid leukemia, myelodysplastic syndrome and juvenile chronic myelocytic leukemia.

11 July 2018

1 reference

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A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development

11 July 2018

1 reference

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Occurrence of myeloproliferative disorder in patients with Noonan syndrome

11 July 2018

1 reference

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Juvenile myelomonocytic leukemia: molecular understanding and prospects for therapy

11 July 2018

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Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

11 July 2018

1 reference

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STATs: signal transducers and activators of transcription

11 July 2018

1 reference

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Juvenile chronic myelogenous leukemia

11 July 2018

1 reference

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Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

11 July 2018

1 reference

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Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders

11 July 2018

1 reference

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SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

11 July 2018

1 reference

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Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

11 July 2018

1 reference

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Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation

11 July 2018

1 reference

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Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways

11 July 2018

1 reference

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The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells

11 July 2018

1 reference

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Signal transduction through small GTPases—A tale of two GAPs

11 July 2018

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Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial.

11 July 2018

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Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

24 September 2018

1 reference

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Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

24 September 2018

1 reference

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Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

24 September 2018

1 reference

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Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders

24 September 2018

1 reference

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Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras

24 September 2018

1 reference

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Juvenile chronic myelogenous leukemia: characterization of the disease using cell cultures

24 September 2018

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12 December 2020

Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors

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12 December 2020

The NF1 gene in myelopoiesis and childhood myelodysplastic syndromes

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12 December 2020

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development

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12 December 2020

10.1182/BLOOD-2004-10-4002

Identifiers

DOI

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10 August 2017

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10 August 2017

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