STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE. (Q35819291)

10 August 2017

STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE. (English)

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10 August 2017

Ian L McWilliams

1

1 reference

10 August 2017

Rajani Rajbhandari

2

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10 August 2017

Susan Nozell

3

1 reference

10 August 2017

Etty Benveniste

4

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10 August 2017

Laurie E Harrington

5

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10 August 2017

30 June 2015

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Journal of Neuroinflammation

10 August 2017

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10 August 2017

12

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10 August 2017

128

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https://scigraph.springernature.com/pub.10.1186/s12974-015-0351-3

10 August 2017

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cites work

STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation

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IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms

11 July 2018

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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

11 July 2018

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Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation

11 July 2018

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Cutting edge: the pathogenicity of IFN-γ-producing Th17 cells is independent of T-bet

11 July 2018

1 reference

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STATs shape the active enhancer landscape of T cell populations

11 July 2018

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Induction and molecular signature of pathogenic TH17 cells

11 July 2018

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Mechanisms regulating regional localization of inflammation during CNS autoimmunity.

11 July 2018

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Autoreactive Tbet-positive CD4 T cells develop independent of classic Th1 cytokine signaling during experimental autoimmune encephalomyelitis

11 July 2018

1 reference

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T(H)17 cytokines in autoimmune neuro-inflammation.

11 July 2018

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RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.

11 July 2018

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The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.

11 July 2018

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Fate mapping of IL-17-producing T cells in inflammatory responses

11 July 2018

1 reference

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T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

11 July 2018

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Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

11 July 2018

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Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation

11 July 2018

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Th1 versus Th17: are T cell cytokines relevant in multiple sclerosis?

11 July 2018

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EAE mediated by a non-IFN-γ/non-IL-17 pathway

11 July 2018

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Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage

11 July 2018

1 reference

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Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming

11 July 2018

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Autoimmune T cell responses in the central nervous system

11 July 2018

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A vital role for interleukin-21 in the control of a chronic viral infection

11 July 2018

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The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

11 July 2018

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Late developmental plasticity in the T helper 17 lineage

11 July 2018

1 reference

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Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis.

11 July 2018

1 reference

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STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease

11 July 2018

1 reference

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The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes

11 July 2018

1 reference

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IL-23 and IL-12 responses in activated human T cells retrovirally transduced with IL-23 receptor variants

11 July 2018

1 reference

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IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491892

Colony-stimulating factors in inflammation and autoimmunity.

11 July 2018

1 reference

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A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491892

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491892

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491892

Interleukin-12 and the regulation of innate resistance and adaptive immunity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491892

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491892

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491892

Immunologic therapy of multiple sclerosis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491892

A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491892

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491892

IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491892

GM-CSF: the secret weapon in the T(H)17 arsenal

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491892

Memory CD4 T cells emerge from effector T-cell progenitors.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491892

IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination

24 September 2018

1 reference

12 December 2020

Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system

1 reference

12 December 2020

Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis

1 reference

12 December 2020

Immunology of multiple sclerosis

1 reference

12 December 2020

GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis

1 reference

12 December 2020

10.1186/S12974-015-0351-3

Identifiers

DOI

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Dimensions Publication ID

10 August 2017

0 references

1 reference

10 August 2017

1 reference