Bioactivation and resistance to mitomycin C. (Q35718407)

9 August 2017

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title

Bioactivation and resistance to mitomycin C. (English)

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9 August 2017

Helen A Seow

1

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9 August 2017

Philip G Penketh

series ordinal

2

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9 August 2017

Raymond P Baumann

series ordinal

3

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9 August 2017

Alan C Sartorelli

series ordinal

4

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9 August 2017

language of work or name

English

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publication date

1 January 2004

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9 August 2017

Methods in Enzymology

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9 August 2017

382

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9 August 2017

221-233

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The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour

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A MOLECULAR MECHANISM OF MITOMYCIN ACTION: LINKING OF COMPLEMENTARY DNA STRANDS

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Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA

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Studies on the mechanism of the cytotoxic action of the mitomycin antibiotics in hypoxic and oxygenated EMT6 cells

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Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C

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The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity

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The major mitomycin C-DNA monoadduct is cytotoxic but not mutagenic in Escherichia coli

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Structure of adduct X, the last unknown of the six major DNA adducts of mitomycin C formed in EMT6 mouse mammary tumor cells

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Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol

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MITOMYCINS AND PORFIROMYCIN: CHEMICAL MECHANISM OF ACTIVATION AND CROSS-LINKING OF DNA.

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Reductive activation of mitomycin C by neuronal nitric oxide synthase

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Metabolic activation of mitomycin C by NADPH-ferredoxin reductase in vitro

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Enzymology of mitomycin C metabolic activation in tumour tissue: implications for enzyme-directed bioreductive drug development

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DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.

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NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals

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Inhibition of DNA cross-linking by mitomycin C by peroxidase-mediated oxidation of mitomycin C hydroquinone

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Reductive activation of mitomycin C

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Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae

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Inducible synthesis of the mitomycin C resistance gene product (MCRA) from Streptomyces lavendulae.

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Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA

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Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase

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The intracellular location of NADH:cytochrome b5 reductase modulates the cytotoxicity of the mitomycins to Chinese hamster ovary cells

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Nuclear overexpression of NADH:cytochrome b5 reductase activity increases the cytotoxicity of mitomycin C (MC) and the total number of MC-DNA adducts in Chinese hamster ovary cells

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7 January 2021

Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphorase

1 reference

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DT-diaphorase activity and mitomycin C sensitivity in non-transformed cell strains derived from members of a cancer-prone family.

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Studies on the mechanism of resistance to mitomycin C and porfiromycin in a human cell strain derived from a cancer-prone individual

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The role of NAD(P)H:quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells

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AlkB mystery solved: oxidative demethylation of N1-methyladenine and N3-methylcytosine adducts by a direct reversal mechanism.

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Characterization of a mitomycin-binding drug resistance mechanism from the producing organism, Streptomyces lavendulae

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Novel selection marker for mammalian cell transfection

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The Fanconi anemia complementation group A protein contains a peroxidase domain.

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Functional analysis of the putative peroxidase domain of FANCA, the Fanconi anemia complementation group A protein

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Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

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Expression of cell surface P-glycoprotein by an adriamycin-resistant murine fibrosarcoma.

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Cytotoxicity and DNA crosslinks produced by mitomycin analogs in aerobic and hypoxic EMT6 cells.

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Mitomycin resistance in Streptomyces lavendulae includes a novel drug-binding-protein-dependent export system

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Identifiers

DOI

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9 August 2017

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