New insights into the integrated physiology of insulin action (Q35711985)

9 August 2017

1 reference

title

New insights into the integrated physiology of insulin action (English)

1 reference

9 August 2017

1 reference

0 references

2

Domenico Accili

1 reference

9 August 2017

Yukari Kitamura

1

1 reference

9 August 2017

1 May 2004

1 reference

Reviews in Endocrine and Metabolic Disorders

9 August 2017

1 reference

9 August 2017

5

1 reference

9 August 2017

2

1 reference

9 August 2017

143-149

1 reference

https://scigraph.springernature.com/pub.10.1023/b:remd.0000021436.91347.93

9 August 2017

0 references

cites work

Insulin: new roles for an ancient hormone

1 reference

12 December 2020

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

1 reference

12 December 2020

Insights into insulin resistance and type 2 diabetes from knockout mouse models

1 reference

12 December 2020

Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells.

1 reference

12 December 2020

Genetics of type 2 diabetes: insight from targeted mouse mutants

1 reference

12 December 2020

Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

1 reference

12 December 2020

Mosaic analysis of insulin receptor function

1 reference

12 December 2020

Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice

1 reference

12 December 2020

Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance

1 reference

12 December 2020

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

1 reference

12 December 2020

Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes

1 reference

12 December 2020

Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B.

1 reference

12 December 2020

Muscle-specific Pparg deletion causes insulin resistance

1 reference

12 December 2020

A link between insulin resistance and hyperinsulinemia: inhibitors of phosphatidylinositol 3-kinase augment glucose-induced insulin secretion from islets of lean, but not obese, rats.

1 reference

12 December 2020

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

1 reference

12 December 2020

In vivo mutagenesis of the insulin receptor

1 reference

12 December 2020

Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model.

1 reference

12 December 2020

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

1 reference

12 December 2020

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

1 reference

12 December 2020

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor

1 reference

12 December 2020

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

1 reference

12 December 2020

Searching for type 2 diabetes genes in the post-genome era.

1 reference

12 December 2020

Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia.

1 reference

12 December 2020

Insulin-like growth factor-I at physiological concentrations is a potent inhibitor of insulin secretion

1 reference

12 December 2020

A kinase in the life of the beta cell

1 reference

12 December 2020

Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals

1 reference

12 December 2020

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

1 reference

12 December 2020

Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance

1 reference

12 December 2020

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

12 December 2020

Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease

1 reference

12 December 2020

Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes

1 reference

12 December 2020

Increased IGFR activity and glucose transport in cultured skeletal muscle from insulin receptor null mice

1 reference

12 December 2020

Evidence for a circulating islet cell growth factor in insulin-resistant states

1 reference

12 December 2020

Exercise and insulin cause GLUT-4 translocation in human skeletal muscle

1 reference

12 December 2020

Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans

1 reference

12 December 2020

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways.

1 reference

12 December 2020

Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2.

1 reference

12 December 2020

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

1 reference

12 December 2020

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

1 reference

12 December 2020

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

12 December 2020

What if Minkowski had been ageusic? An alternative angle on diabetes

1 reference

12 December 2020

Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

1 reference

12 December 2020

Insulin receptor knockout mice

1 reference

12 December 2020

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

1 reference

12 December 2020

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

1 reference

12 December 2020

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue.

1 reference

12 December 2020

Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia.

1 reference

12 December 2020

Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance

1 reference

12 December 2020

Targeted inactivation of the insulin receptor gene in mouse 3T3-L1 fibroblasts via homologous recombination

1 reference

12 December 2020

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

1 reference

12 December 2020

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

1 reference

12 December 2020

Molecular mechanisms of insulin resistance and the role of the adipocyte

1 reference

12 December 2020

Preserved pancreatic beta-cell development and function in mice lacking the insulin receptor-related receptor

1 reference

12 December 2020

Impaired insulin signaling in skeletal muscles from transgenic mice expressing kinase-deficient insulin receptors

1 reference

12 December 2020

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

1 reference

12 December 2020

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

1 reference

12 December 2020

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

1 reference

12 December 2020

10.1023/B:REMD.0000021436.91347.93

Identifiers

DOI

1 reference

PubMed ID

15041790

Dimensions Publication ID

9 August 2017

1003729508

0 references

Fatcat ID

release_4dfnb3d3vfhm3b7es32zwi6ywu

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4dfnb3d3vfhm3b7es32zwi6ywu

24 November 2022

mapped directly with Wikidata item

PubMed ID

15041790

1 reference

PubMed ID

15041790