5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair (Q35613493)

9 August 2017

5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair (English)

1 reference

9 August 2017

1 reference

1 reference

5

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10 June 2020

Matthias Dobbelstein

7

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10 June 2020

author name string

Upadhyayula Sai Srinivas

1

1 reference

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10 June 2020

Jerzy Dyczkowski

2

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10 June 2020

Tim Beißbarth

3

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10 June 2020

Jochen Gaedcke

4

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10 June 2020

Kerstin Borgmann

6

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10 June 2020

language of work or name

English

0 references

publication date

1 May 2015

1 reference

9 August 2017

1 reference

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10 June 2020

volume

6

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10 June 2020

issue

14

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10 June 2020

page(s)

12574-12586

1 reference

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Exploiting replicative stress to treat cancer

10 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy

12 July 2018

1 reference

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DNA replication stress: causes, resolution and disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

DNA replication and oncogene-induced replicative stress

12 July 2018

1 reference

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Targeting tumour-supportive cellular machineries in anticancer drug development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Rad51 expression is a useful predictive factor for the efficacy of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the esophagus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Behind the wheel and under the hood: functions of cyclin-dependent kinases in response to DNA damage

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Participation of DNA repair in the response to 5-fluorouracil

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

ATR: an essential regulator of genome integrity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Overexpression of DNA repair genes is associated with metastasis: a new hypothesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

DNA repair pathways as targets for cancer therapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Pilot study examining tumor expression of RAD51 and clinical outcomes in human head cancers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Gene Expression Profiling of Primary Cutaneous Melanoma and Clinical Outcome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Mechanisms of apoptosis induction by nucleoside analogs.

12 July 2018

1 reference

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5-Fluorouracil: mechanisms of action and clinical strategies

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494959

Over-expression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer

12 July 2018

1 reference

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DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma

12 July 2018

1 reference

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XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

12 July 2018

1 reference

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

12 July 2018

1 reference

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Primary prevention of colorectal cancer. The WHO Collaborating Centre for the Prevention of Colorectal Cancer

12 July 2018

1 reference

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Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status

12 July 2018

1 reference

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Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses.

25 September 2018

1 reference

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High expression of DNA repair pathways is associated with metastasis in melanoma patients

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25909291

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.3728

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25909291%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

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10 June 2020

1 reference

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