Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury (Q35611333)

9 August 2017

Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury (English)

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9 August 2017

4

Koji Uchida

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9 August 2017

Takashi Toyama

1

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9 August 2017

Yasuhiro Shinkai

2

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9 August 2017

Akira Yasutake

3

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9 August 2017

Masayuki Yamamoto

5

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9 August 2017

Yoshito Kumagai

6

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9 August 2017

7 March 2011

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Environmental Health Perspectives

9 August 2017

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9 August 2017

119

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9 August 2017

1117-1122

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9 August 2017

8

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describes a project that uses

9 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3237354/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Selective inhibition of the mouse brain Mn-SOD by methylmercury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells

27 July 2018

1 reference

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Electrophiles in foods: the current status of isothiocyanates and their chemical biology

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Targeting NRF2 signaling for cancer chemoprevention

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction.

27 July 2018

1 reference

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Overview of modifiers of methylmercury neurotoxicity: chemicals, nutrients, and the social environment

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury: a possible mechanism

27 July 2018

1 reference

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Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity

27 July 2018

1 reference

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Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury

27 July 2018

1 reference

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Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Effects of environmental methylmercury on the health of wild birds, mammals, and fish

27 July 2018

1 reference

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Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

27 July 2018

1 reference

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Chemoprotection by sulforaphane: keep one eye beyond Keap1.

27 July 2018

1 reference

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Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles

27 July 2018

1 reference

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

27 July 2018

1 reference

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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Methylmercury Poisoning in Iraq

27 July 2018

1 reference

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The effects of methyl mercury binding to microtubules.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Congenital Minamata disease: Intrauterine methylmercury poisoning

27 July 2018

1 reference

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Nuclear magnetic resonance studies of the solution chemistry of metal complexes. XI. Binding of methylmercury by sulfhydryl-containing amino acids and by glutathione

27 July 2018

1 reference

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Adverse effects of methylmercury: environmental health research implications

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Docosahexaenoic acid may act as a neuroprotector for methylmercury-induced neurotoxicity in primary neural cell cultures.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Role of docosahexaenoic acid in modulating methylmercury-induced neurotoxicity

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Brain and blood mercury and selenium after chronic and developmental exposure to methylmercury.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Glutathione modulation influences methyl mercury induced neurotoxicity in primary cell cultures of neurons and astrocytes.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Separation and identification by gel filtration and high-performance liquid chromatography with UV or electrochemical detection of the disulphides produced from cysteine and glutathione oxidation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Transport of toxic metals by molecular mimicry

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Selective involvement of large motor neurons in the spinal cord of rats treated with methylmercury.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Reduced methylmercury accumulation in a methylmercury-resistant rat pheochromocytoma PC12 cell line

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Methyl mercury binding substances from the brain of experimentally exposed squirrel monkeys (Saimiri sciureus).

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237354

Accelerated urinary excretion of methylmercury following administration of its antidote N-acetylcysteine requires Mrp2/Abcc2, the apical multidrug resistance-associated protein

25 September 2018

1 reference

12 December 2020

Sulfobromophthalein inhibition of glutathione and methylmercury secretion into bile

1 reference

12 December 2020

Inhibitory effect of selenium on biliary secretion of methyl mercury in rats

1 reference

12 December 2020

Biliary transport of glutathione and methylmercury

1 reference

12 December 2020

Serum levels of orally administered penicillin

1 reference

12 December 2020

Maternal selenium deficiency enhances the fetolethal toxicity of methyl mercury.

1 reference

12 December 2020

Mechanism of methylmercury efflux from cultured astrocytes

1 reference

12 December 2020

Identifiers

DOI

10.1289/EHP.1003123

1 reference

9 August 2017

1 reference

9 August 2017

1 reference