Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia. (Q35602348)

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29 February 2020

title

Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia (English)

1 reference

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29 February 2020

0 references

9

1 reference

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29 February 2020

Tanja N Hartmann

10

1 reference

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29 February 2020

Fritz Aberger

11

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29 February 2020

author name string

D Kern

1

1 reference

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29 February 2020

G Regl

2

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29 February 2020

S W Hofbauer

3

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29 February 2020

P Altenhofer

4

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29 February 2020

G Achatz

5

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29 February 2020

A Dlugosz

6

1 reference

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29 February 2020

H Schnidar

7

1 reference

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29 February 2020

R Greil

8

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29 February 2020

language of work or name

English

0 references

publication date

2 February 2015

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29 February 2020

1 reference

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29 February 2020

volume

34

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29 February 2020

issue

42

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29 February 2020

page(s)

5341-5351

1 reference

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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International

29 February 2020

copyright license

start time

2 February 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/onc.2014.450

0 references

cites work

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Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL.

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Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish

12 July 2018

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12 July 2018

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12 July 2018

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Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway

12 July 2018

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GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.

12 July 2018

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Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

12 July 2018

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GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

12 July 2018

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Basal cell carcinomas: attack of the hedgehog

12 July 2018

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The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

12 July 2018

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

12 July 2018

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Arsenic trioxide decreases AKT protein in a caspase-dependent manner

12 July 2018

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Efficient manipulation of Hedgehog/GLI signaling using retroviral expression systems.

12 July 2018

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The Gli code: an information nexus regulating cell fate, stemness and cancer.

12 July 2018

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Patched1 regulates hedgehog signaling at the primary cilium

12 July 2018

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Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo

12 July 2018

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Essential role of stromally induced hedgehog signaling in B-cell malignancies

12 July 2018

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Hedgehog signaling pathway in neural development and disease.

12 July 2018

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Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

12 July 2018

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Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

12 July 2018

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

12 July 2018

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Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli.

12 July 2018

1 reference

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Hedgehog/Ras interactions regulate early stages of pancreatic cancer

12 July 2018

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Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes.

12 July 2018

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Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling

12 July 2018

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Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling

12 July 2018

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Vertebrate Smoothened functions at the primary cilium

12 July 2018

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Cilia and Hedgehog responsiveness in the mouse

12 July 2018

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Communicating with Hedgehogs

12 July 2018

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Richter syndrome: biology, incidence, and therapeutic strategies

12 July 2018

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Tissue repair and stem cell renewal in carcinogenesis

12 July 2018

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Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia

12 July 2018

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The magnitude of hedgehog signaling activity defines skin tumor phenotype

12 July 2018

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Akt is TCL-ish: implications for B-cell lymphoma.

12 July 2018

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Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression

12 July 2018

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Hedgehog signaling in animal development: paradigms and principles

12 July 2018

1 reference

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MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation

12 July 2018

1 reference

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Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide

12 July 2018

1 reference

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B lymphocyte-specific, Cre-mediated mutagenesis in mice

12 July 2018

1 reference

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Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

12 July 2018

1 reference

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

12 July 2018

1 reference

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Combination of ponatinib with Hedgehog antagonist vismodegib for therapy-resistant BCR-ABL1-positive leukemia

12 July 2018

1 reference

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B-cell receptor signaling in chronic lymphocytic leukemia.

25 September 2018

1 reference

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Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

25 September 2018

1 reference

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Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4430320

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4430320

Arsenic trioxide induces apoptosis preferentially in B-CLL cells of patients with unfavourable prognostic factors including del17p13.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4430320

Patching the gaps in Hedgehog signalling

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4430320

Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4430320

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2014.450

21 January 2018

Identifiers

DOI

10.1038/ONC.2014.450

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25639866%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25639866%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25639866%20AND%20SRC:MED&resulttype=core&format=json