The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis (Q27619877)

2

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P R Mittl

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S D Marco

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J F Krebs

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J C Wu

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K J Tomaselli

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M G Grütter

Mechanisms and Functions of Cell Death

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publication date

15 September 1999

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language of work or name

1 reference

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7

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issue

9

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page(s)

1125-33

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cites work

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Mechanisms and genes of cellular suicide

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Apoptotic pathways: the roads to ruin

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Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

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Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

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An induced proximity model for caspase-8 activation.

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Pro-caspase-3 is a major physiologic target of caspase-8.

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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Caspases: killer proteases

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

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7 January 2021

Neuroprotection by a caspase inhibitor in acute bacterial meningitis

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Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

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Apoptosis in the pathogenesis and treatment of disease

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A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis

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A caspase inhibitor blocks ischaemia‐induced delayed neuronal death in the gerbil

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Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

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7 January 2021

Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro

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7 January 2021

Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

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Structure and mechanism of interleukin-1 beta converting enzyme

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Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone

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7 January 2021

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

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Inhibition of human caspases by peptide-based and macromolecular inhibitors

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A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

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7 January 2021

Prediction of the tertiary structure and substrate binding site of caspase‐8

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

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Bcl-xL Functions Downstream of Caspase-8 to Inhibit Fas- and Tumor Necrosis Factor Receptor 1-induced Apoptosis of MCF7 Breast Carcinoma Cells

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AMoRe: an automated package for molecular replacement

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Improved methods for building protein models in electron density maps and the location of errors in these models

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The CCP4 suite: programs for protein crystallography

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Improved Fourier coefficients for maps using phases from partial structures with errors

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PROCHECK: a program to check the stereochemical quality of protein structures

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SETOR: hardware-lighted three-dimensional solid model representations of macromolecules

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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Evaluation of single-crystal X-ray diffraction data from a position-sensitive detector

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