Probing dopamine transporter structure and function by Zn2+-site engineering (Q35581525)

9 August 2017

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title

Probing dopamine transporter structure and function by Zn2+-site engineering (English)

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9 August 2017

membrane glycoprotein

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612149

31 March 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

31 March 2024

1

Claus Juul Loland

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612149

31 March 2024

3

Ulrik Gether

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612149

31 March 2024

author name string

Kristine Norgaard-Nielsen

2

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9 August 2017

language of work or name

English

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publication date

1 October 2003

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9 August 2017

31 October 2003

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14612149

full work available at URL

31 March 2024

https://api.elsevier.com/content/article/PII:S0014299903023215?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

https://api.elsevier.com/content/article/PII:S0014299903023215?httpAccept=text/plain

31 March 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

European Journal of Pharmacology

31 March 2024

published in

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9 August 2017

479

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9 August 2017

1-3

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9 August 2017

187-197

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Analysis of zinc binding sites in protein crystal structures

9 August 2017

1

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https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Zinc coordination sphere in biochemical zinc sites.

31 March 2024

2

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https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

31 March 2024

3

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

The galvanization of biology: a growing appreciation for the roles of zinc

31 March 2024

4

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

External cysteine residues in the serotonin transporter

31 March 2024

6

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Structure and function of the dopamine transporter

31 March 2024

7

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https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Permeation and gating residues in serotonin transporter

31 March 2024

8

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https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor.

31 March 2024

9

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+

31 March 2024

10

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https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Design, synthesis, and characterization of a novel, 4-[2-(diphenylmethoxy)ethyl]-1-benzyl piperidine-based, dopamine transporter photoaffinity label

31 March 2024

11

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor.

31 March 2024

13

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Metal-ion sites as structural and functional probes of helix-helix interactions in 7TM receptors.

31 March 2024

14

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Dendrodendritic inhibition through reversal of dopamine transport

31 March 2024

15

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors.

31 March 2024

16

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https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Synaptically released zinc: physiological functions and pathological effects.

31 March 2024

18

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https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

31 March 2024

19

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Projection structure and molecular architecture of OxlT, a bacterial membrane transporter.

31 March 2024

21

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https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor.

31 March 2024

23

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors

31 March 2024

24

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https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Simple Allosteric Model for Membrane Pumps

31 March 2024

27

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding

31 March 2024

28

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors.

31 March 2024

29

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

31 March 2024

30

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Carrier-mediated release of neurotransmitters

31 March 2024

31

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Induction of mossy fiber --> Ca3 long-term potentiation requires translocation of synaptically released Zn2+.

31 March 2024

32

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Rapid translocation of Zn(2+) from presynaptic terminals into postsynaptic hippocampal neurons after physiological stimulation.

31 March 2024

33

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism

31 March 2024

34

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression.

31 March 2024

35

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains.

31 March 2024

36

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.

31 March 2024

37

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

31 March 2024

38

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Engineered Zn(2+) switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents

31 March 2024

39

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.

31 March 2024

40

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Osmochemistry of solute translocation

31 March 2024

41

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https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Zn(2+) site engineering at the oligomeric interface of the dopamine transporter.

31 March 2024

42

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Delineation of an endogenous zinc-binding site in the human dopamine transporter

31 March 2024

44

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

31 March 2024

45

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter

31 March 2024

46

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons

31 March 2024

47

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor

31 March 2024

48

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

The role of zinc ions in reverse transport mediated by monoamine transporters.

31 March 2024

51

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Zinc mining for protein domains

31 March 2024

52

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

The rat serotonin transporter: identification of cysteine residues important for substrate transport

31 March 2024

53

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Allosteric modulation of beta2-adrenergic receptor by Zn(2+).

31 March 2024

54

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Identification of an allosteric binding site for Zn2+ on the beta2 adrenergic receptor

31 March 2024

55

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Construction of a high affinity zinc switch in the kappa-opioid receptor.

31 March 2024

56

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Plasma membrane monoamine transporters: structure, regulation and function

31 March 2024

57

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

The biochemical basis of zinc physiology

31 March 2024

58

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions.

31 March 2024

59

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Quaternary structure and function of transport proteins

31 March 2024

60

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

The actions of synaptically released zinc at hippocampal mossy fiber synapses.

31 March 2024

61

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Distance determination in proteins using designed metal ion binding sites and site-directed spin labeling: application to the lactose permease of Escherichia coli

31 March 2024

62

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

A method for distance determination in proteins using a designed metal ion binding site and site-directed spin labeling: evaluation with T4 lysozyme

31 March 2024

63

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Dopamine transporter cysteine mutants: second extracellular loop cysteines are required for transporter expression.

31 March 2024

64

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https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons.

31 March 2024

65

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https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Three-dimensional structure of the ion-coupled transport protein NhaA.

31 March 2024

66

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Projection structure of NhaA, a secondary transporter from Escherichia coli, at 4.0 A resolution

31 March 2024

67

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter

31 March 2024

68

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https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

Novel tropane-based irreversible ligands for the dopamine transporter

31 March 2024

69

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https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

31 March 2024

Identifiers

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9 August 2017

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